Senior Director, Oncology Pharmacology

Location: Remote/Home-Based; London, UK; California, Palo Alto, CA; or Philadelphia, PA.

Base salary: $232,000–$348,000 annually for US-based candidates, plus potential bonus, equity, and benefits.

Company

Global biopharmaceutical organization developing medicines for serious diseases, with marketed therapies and a growing oncology pipeline.

What you will do

• Lead scientific team members and oncology assets from discovery through regulatory approval while serving as a program lead on selected assets.
• Establish efficacy, tolerability, pharmacokinetic/pharmacodynamic relationships, mechanisms of action, predictive models, indications, and biomarkers.
• Design and execute in-house, outsourced, and academic studies across small molecules, biologics, ADCs, bispecifics, cell therapies, and other emerging modalities.
• Lead cross-functional oncology teams with Clinical Development, Bioanalytical, Toxicology, Clinical Pharmacology, Biomarkers, Regulatory Affairs, and Project Management.
• Oversee CRO protocols, timelines, budgets, study execution, data interpretation, technical reports, and regulatory documents.
• Mentor junior scientists, represent pharmacology in project teams, and communicate research findings to internal and external audiences.

Requirements

• Industry experience evaluating therapeutic candidates from hit-to-lead optimization through discovery and late-phase studies, with deep oncology drug-development expertise.
• Extensive immuno-oncology experience, including relevant in-vivo and in-vitro models, immune-cell biology, and integration of immunological endpoints.
• Experience across multiple modalities, including small molecules, biologics, ADCs, bispecifics, T-cell engagers, cell and gene therapies, and RNA-based therapeutics.
• Deep understanding of cancer-signaling pathways and their therapeutic exploitation.
• Ph.D. in biology, biochemistry, immunology, pharmacology, or a related discipline, with substantial oncology and immuno-oncology experience.
• Strong understanding of the interdependencies between nonclinical pharmacology, toxicology, DMPK, and clinical pharmacology for dose selection, therapeutic-index characterization, risk assessment, and translational strategy.
• Experience leading complex pharmacology programs across CROs in GLP and non-GLP environments and designing efficacy, tolerability, mechanism-of-action, and biomarker studies.
• Ability to integrate preclinical and clinical datasets, apply novel methodologies, analyze data, and use tools such as GraphPad Prism and biomarker-analysis methods.
• Direct people-management experience, strong leadership, mentoring, negotiation, influence, networking, analytical problem-solving, and project-management skills in highly matrixed environments.
• Experience overseeing CRO activities, developing and reviewing protocols, monitoring execution, interpreting results, and preparing regulatory-quality reports and nonclinical components of IND, NDA/BLA/MAA submissions, briefing packages, DSURs, IBs, and fast-track designation documents.
• Ability to model organizational core values and drive decisions across diverse stakeholders, academia, industry, and regulatory agencies.

Culture & Benefits

• Remote/home-based work arrangement for the listed locations.
• Cross-functional collaboration in a highly matrixed research and development environment.
• Medical, dental, and vision insurance for eligible US-based employees.
• 401(k) retirement savings plan, flexible paid vacation, potential annual cash bonus, and discretionary equity grants for eligible US-based employees.