Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity)

Location: San Francisco, United States; onsite role

Salary: $200,000–$240,000 USD annually, plus stock options and an annual bonus program.

Company

hirify.global is a precision medicines biotechnology company developing therapies for autoimmune diseases.

What you will do

• Lead biology strategy for discovery-stage small molecule projects, including target identification, knowledge-gap analysis, screening paradigms, and SAR generation.
• Oversee biochemical and cellular read-outs supporting small molecule drug discovery.
• Characterize clinical candidates using autoimmune disease models and clinically relevant pharmacodynamic assays.
• Supervise laboratory-based biology staff directly and indirectly, while mentoring junior employees.
• Manage external biology studies conducted by CROs.
• Coordinate with medicinal chemistry, DMPK, preclinical development, and company leadership on project strategy and progress.

Requirements

• PhD and 8+ years of biopharma experience in immunology-related small molecule drug discovery.
• Experience overseeing project biology or biochemistry functions and/or leading project teams.
• Expertise across target discovery and validation through early clinical development.
• Hands-on knowledge of protein-protein interaction inhibitors, degraders, molecular glues, transcription factors, compound screening, mechanism-of-action characterization, transcriptomics, and proteomics.
• Experience with autoimmune disease biology, in vitro and in vivo immunology models, primary immune cells, immortalized cell lines, RNA-Seq, and cytokine detection.
• Experience managing CRO collaborations and supervising junior staff, with strong independent and cross-functional collaboration skills.

Nice to have

• Experience working with academic collaborators.
• Familiarity and enthusiasm for working in a small company environment.
• Track record of scientific achievement and innovation.

Culture & Benefits

• Collaborative environment focused on elevating, challenging, and nurturing colleagues.
• Health insurance premiums covered at 90% for employees and 80% for dependents.
• Stock option grants and an annual bonus program.
• Unlimited PTO for exempt employees.
• Free onsite gym, stocked kitchen, and access to the Genentech Bus & Ferry Share program.
• $100 monthly cell phone stipend.