Principal Scientist, Inflammation (Immunology)

Location: South San Francisco, California, United States

Salary: $153,524.45–$207,709.55 annually

Company

hirify.global is a biotechnology company developing medicines across oncology, inflammation, general medicine, and rare disease.

What you will do

• Lead discovery and translational biology for an immune-targeting therapeutic platform focused on autoimmune and inflammatory diseases.
• Design and execute in vitro, ex vivo, and in vivo studies assessing immune-cell activity, target-cell depletion, immune pharmacology, and response durability.
• Develop functional immune-cell assays, co-culture systems, cytotoxicity assays, and pharmacodynamic readouts.
• Build translational biology capabilities covering immune-cell profiling, biodistribution, and pharmacodynamic biomarker development.
• Integrate experimental datasets to guide platform optimization, candidate selection, and preclinical program progression.
• Collaborate across discovery biology, protein engineering, delivery sciences, in vivo pharmacology, and translational safety while presenting scientific conclusions.

Requirements

• PhD, PharmD, or MD with relevant experience; alternatively, a master’s degree with 5 years or a bachelor’s degree with 7 years of experience in drug discovery or academic settings.
• Deep expertise in lymphocyte biology, immune effector mechanisms, and immunology-related research, with more than 5 years of relevant experience preferred.
• Strong expertise in in vitro and ex vivo immunology, primary immune-cell assays, co-culture systems, immune-mediated cytotoxicity or target-cell depletion assays, and high-parameter flow cytometry.
• Experience with preclinical mouse models, immune-cell profiling, pharmacodynamic responses, and mechanism-of-action studies.
• Strong scientific communication, documentation, laboratory management, collaboration, and project coordination skills.

Nice to have

• Experience with ELISA, MSD, single-cell RNA sequencing, CRISPR/Cas9, omics data analysis, and small- or large-molecule drug discovery.
• Publications in high-impact journals and a record of independent scientific contributions.

Culture & Benefits

• Collaborative, innovative, science-based working environment.
• Health, dental, and vision coverage, life and disability insurance, and flexible spending accounts.
• Retirement and savings plan with company contributions, stock-based incentives, and an annual bonus program.
• Paid time-off programs and career development opportunities.
• Flexible work models may be available where applicable to the role.

Hiring process

• Applications are accepted until a candidate is selected; there is no fixed application deadline.
• Sponsorship for this role is not guaranteed.