Scientist I, In Vivo Pharmacology (Oncology)

Location: Onsite in North Chicago, Illinois, United States

Salary: $75,000–$142,500 per year

Company

hirify.global discovers and develops medicines and solutions for serious health conditions, with a focus on areas including immunology, oncology, neuroscience, and aesthetics.

What you will do

• Independently execute, monitor, and interpret in vivo mouse cancer studies, including CDX, PDX, disseminated, and syngeneic models.
• Evaluate novel small-molecule and biologic cancer therapeutics through efficacy, pharmacokinetic, and tolerability studies.
• Collect and prepare tumor-study tissues for downstream pharmacodynamic analyses, including IHC, flow cytometry, and RNA sequencing.
• Identify, validate, and use humanized mouse models to support oncology pipeline assets.
• Interpret multistage experimental results, draw conclusions, and design follow-up studies aligned with project goals.
• Develop novel in vivo approaches and experimental protocols to address complex biological questions.

Requirements

• BS degree with 5+ years of experience or MS degree with 2+ years of experience in physiology, pharmacology, molecular biology, or a related biology field.
• Strong expertise in in vivo experimentation, including animal health monitoring, tumor implantation, tumor measurement, dosing by IP, IV, SC, and PO routes, and blood or tissue collection.
• Experience designing and executing studies in immunocompromised and immunocompetent mice.
• Ability to communicate effectively and collaborate with in vitro biology, translational and biomarker, and medicinal chemistry teams.
• Ability to perform routine and complex experimental tasks independently and interpret study data.

Nice to have

• Experience with huPBMC and CD34 humanized mice.
• Experience with CDX and/or PDX xenograft mouse models of cancer.
• Experience with ADC or T-cell engager therapeutics.
• Familiarity with Microsoft Office, Study Director, GraphPad Prism, data management, and statistical analysis.

Culture & Benefits

• Collaborative, multidisciplinary research environment focused on advancing novel oncology science.
• Paid time off, including vacation, holidays, and sick leave.
• Medical, dental, and vision insurance for eligible employees.
• 401(k) benefits for eligible employees.
• Eligibility to participate in short-term incentive programs.