Research Scientist I/II (Immunology)

Location: Onsite at the San Diego headquarters, United States

Salary: Research Scientist I $113,000–$142,000 annually; Research Scientist II $124,000–$156,000 annually

Company

hirify.global Therapeutics is a clinical-stage life science and technology company developing medicines through an AI-driven drug discovery and development platform.

What you will do

• Design, optimize, troubleshoot, and execute in vitro and ex vivo immunology assays using primary human and preclinical immune cells, whole blood, cell lines, and tissue-derived systems.
• Measure potency, selectivity, target engagement, mechanism of action, and functional immune responses for small-molecule discovery programs.
• Generate reproducible compound-profiling data to support hit-to-lead, lead optimization, and development candidate selection.
• Apply quantitative pharmacology and data-quality practices to analyze concentration-response relationships, assay performance, and biological relevance.
• Support in vivo immunology studies through experimental planning, sample processing, ex vivo analyses, and interpretation of PK/PD, biomarker, exposure, and efficacy data.
• Maintain laboratory records and support assay transfers, CRO studies, reagent and instrument qualification, and method documentation.

Requirements

• PhD in immunology or a related biological discipline with immunology-focused postdoctoral training and 0–4 years of relevant experience, or MS with 7+ years / BS with 9+ years of relevant experience.
• Strong knowledge of innate and/or adaptive immunology, immune-cell signaling, and disease-relevant mechanisms.
• Hands-on experience with in vitro and ex vivo immunology studies using primary human or animal immune cells, whole blood, or tissue-based systems.
• Proficiency in multiparameter flow cytometry, cytokine and chemokine assays, and complementary functional or molecular readouts.
• Ability to develop, troubleshoot, and document robust cell-based assay cascades with controls, counterscreens, and orthogonal readouts.
• Working knowledge of in vivo immunology and pharmacology, including model selection, dosing, endpoints, tissue collection, PK/PD, and pharmacodynamic biomarkers.

Nice to have

• Experience transferring assays to CROs or automated and high-throughput screening platforms.
• Experience with compound screening or profiling and exposure to hit identification, hit-to-lead, or lead optimization.
• Direct hands-on experience supporting in vivo immunology studies.

Culture & Benefits

• Collaborative, bench-focused environment emphasizing scientific rigor, safety, organization, and timely execution.
• Cross-functional collaboration across biology, medicinal chemistry, DMPK, in vivo pharmacology, computational biology, machine learning, and compound management.
• Company-paid healthcare, flexible spending accounts, voluntary life insurance, and 401(k) matching.
• Uncapped vacation and access to a state-of-the-art facility with an onsite gym and dining.
• Inclusive culture supporting diversity across backgrounds, cultures, national origins, religions, sexual orientations, and life experiences.