Senior / Principal Associate Scientist, Advanced Cell Engineering (mRNA Therapeutics)

Location: Boston, Massachusetts, United States

Salary: $84,000–$112,000 annually, plus bonus and equity incentives

Company

hirify.global is a clinical-stage biotechnology company developing programmable mRNA therapeutics through its Signal Stack platform, with an initial focus on oncology and autoimmune disease.

What you will do

• Design and execute in vitro immunological and cellular assays to characterize and optimize engineered primary cells.
• Develop ex vivo sample-processing protocols and perform multiparameter spectral flow cytometry using Cytek Aurora.
• Isolate, culture, manipulate, and transfect primary immune cells with mRNA-encoded therapeutics.
• Design immune-cell assays to assess drug-candidate efficacy and potential toxicity.
• Apply cell-based and molecular-biology assays to evaluate research-material quality.
• Capture, analyze, and summarize data in electronic laboratory notebooks, databases, study reports, and cross-functional meetings.

Requirements

• B.S. or M.S. in biological sciences, bioengineering, or a related discipline, with at least 2–3+ years of relevant cell-biology or immunology experience.
• 3–5+ years of experience with flow-cytometry analysis, cell culture, and in vitro experimentation with mammalian cell lines.
• Theoretical and practical flow-cytometry expertise, including designing and executing panels with more than 12 colors.
• Experience working with whole blood, PBMCs, cell lines, and single-cell suspensions from tissue samples.
• Ability to write, edit, and follow SOPs; maintain complete laboratory records; and communicate results in cross-functional meetings.
• Proficiency with Excel, PowerPoint, GraphPad Prism, FlowJo, and ELN/LIMS.

Nice to have

• mRNA transfection using LNPs or electroporation, including transfection and transduction of primary cells.
• In vitro or ex vivo cytotoxicity assays, proliferation assays, ELISA/MSD, plasmid cloning, RNA handling, and IVT.
• Experience with gene or base editors.
• Familiarity with Hamilton liquid handlers or AssistPlus lab-automation systems.

Culture & Benefits

• Fast-paced, entrepreneurial, team-focused small-company environment.
• Health, dental, and life insurance.
• Open PTO, onsite lunch catering, and commuter support.
• Work/life flexibility, professional-development support, bonus, and equity incentives.
• High-integrity environment with strict compliance standards.