4 часа назад
Scientist, Immunology
120 000 - 175 000$
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Scientist, Immunology (Cell-Based Assays): Designing and optimizing cellular assays to evaluate the mechanism of action of small-molecule hits and support hit-to-lead and lead optimization with an accent on immunology, immune signaling, and primary cell techniques. Focus on developing medium- to high-throughput dose-response assays, generating IC50 data, interpreting experimental results, and guiding decisions across multidisciplinary drug discovery teams.
Location: Monrovia, CA, United States; full-time onsite
Salary: $120,000–$175,000 annually, depending on experience, plus bonus.
Company
is a venture-backed biotechnology company combining nanotechnology, experimental science, machine learning, and automation to discover and develop small-molecule medicines.
What you will do
- Review scientific literature to understand therapeutic targets and relevant immune biology.
- Design cellular experiments to confirm the mechanism of action of small-molecule hits from binding and virtual screens.
- Develop, optimize, and run cell-based assays to profile on-target and off-target activity.
- Adapt assays for medium- to high-throughput screening, dose-response analysis, and IC50 generation.
- Manage CROs supporting reagent development and in vitro testing.
- Analyze experimental data, communicate findings, and represent immunology in multidisciplinary project teams.
Requirements
- PhD in immunology, molecular biology, cell biology, or a related field with 3+ years of small-molecule drug discovery experience, or an MSc with 10+ years of relevant industry experience.
- Strong knowledge of immunology and immune signaling pathways.
- Extensive hands-on experience with cell culture and cell-based assays, including reporter assays, flow cytometry, qPCR, RNAseq, Luminex, MSD, ELISA, Western blotting, and intracellular techniques.
- Proficiency in primary cell isolation, differentiation, culture, and flow cytometry.
- Experience establishing robust small-molecule dose-response assays and generating IC50 data.
- Strong troubleshooting, organizational, interpersonal, communication, and collaborative research skills.
Culture & Benefits
- Hands-on, collaborative environment connecting experimental scientists, chemists, computational scientists, automation specialists, and engineers.
- Fast-paced work focused on solving complex technical problems and advancing drug discovery.
- Stock option plan participation.
- 3% retirement safe harbor contribution.
- Fully paid health, dental, and vision insurance for employees and families, plus life and disability coverage.
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