Senior Scientist, Cellular Pharmacology (Ophthalmology/Neuroscience)

TL;DR

Senior Scientist (iPSC/Drug Discovery): Characterizing large molecule drug candidates using iPSC-derived cellular and organoid models with an accent on in vitro pharmacological characterization for ophthalmology and neuroscience. Focus on architecting complex screening cascades, implementing high-throughput workflows, and driving lead candidate selection through quantitative analysis.

Location: South San Francisco, California, USA

Salary: $124,300 – $230,900

Company

hirify.global, a member of the Roche group and biotechnology pioneer, is dedicated to discovering and developing medicines for serious and life-threatening diseases.

What you will do

• Lead the development, optimization, and execution of innovative functional pharmacology assays using complex iPSC-derived cellular and engineered organoid/tissue models.
• Drive the selection and advancement of lead drug candidates across multiple disease indications through rigorous in vitro characterization.
• Collaborate with multidisciplinary teams, including Discovery Research, Protein Sciences, Structural Biology, and Safety Assessment.
• Design and implement robust, high-throughput sample preparation and data analysis workflows in coordination with automation and bioinformatics specialists.
• Architect complex screening cascades and present findings to project teams and senior leadership.
• Oversee third-party vendors and CRO partnerships to ensure quality execution and timely delivery of data.

Requirements

• Ph.D. in molecular and cellular biology, ophthalmology, neuroscience, or a related field.
• Minimum of 3 years postdoctoral or pharmaceutical experience with a strong record of high-profile publications.
• Prior experience with ophthalmology/neuroscience therapeutics in drug discovery is required.
• Hands-on experience with iPSCs, including differentiation for disease modeling and CRISPR gene editing.
• Proven ability to work seamlessly across cross-functional project teams while maintaining scientific independence.
• Expertise in quantitative methods and a resilient experimental approach.

Nice to have

• Experience with in vitro drug screening and functional assays.
• Experience with automated or semi-automated instrumentation and AI/ML applications.
• Previous pharmaceutical or biotech industry experience in relevant models.

Culture & Benefits

• Relocation benefits are available for this position.
• Discretionary annual bonus based on individual and company performance.
• Comprehensive benefits package provided by hirify.global.
• Work environment focused on groundbreaking science and solving complex health challenges.