Scientist I / II, mRNA Translation Dynamics (Synthetic Biology)

TL;DR

Scientist I / II, mRNA Translation Dynamics (Synthetic Biology): Developing high-throughput workflows for decoding mRNA translation dynamics to generate biological datasets for machine learning models with an accent on pooled screening strategies and synthetic biology. Focus on designing and executing Ribo-seq and polysome profiling campaigns and optimizing cell-free and in-cell assay systems.

Location: Cambridge, MA, USA

Salary: $108,000 - $170,000 USD

Company

hirify.global is a scientific superintelligence platform and autonomous lab for life, chemistry, and materials science.

What you will do

• Design and execute high-throughput pooled screening campaigns to interrogate mRNA translation dynamics across diverse contexts.
• Develop and optimize cell-free and in-cell assay systems for quantitative measurement of translation efficiency and kinetics.
• Collaborate with computational and ML teams to define data requirements and validate model predictions.
• Establish next-generation library design strategies using combinatorial and rational approaches.
• Analyze complex biological datasets to distill actionable insights for platform advancement.
• Contribute to the development of automated experimental pipelines to increase throughput and consistency.

Requirements

• MSc with 4+ years of industry or academic experience, or a PhD in molecular biology, bioengineering, synthetic biology, or chemical biology.
• Deep expertise in mRNA biology and translation regulation.
• Experience with next-generation sequencing based assays such as polysome profiling and Ribo-seq.
• Strong quantitative and analytical skills for handling large-scale biological datasets.
• Must be based in or authorized to work in Cambridge, MA, USA.

Nice to have

• Experience integrating experimental data with machine learning or computational modeling pipelines.
• Proficiency in Python, R, or other scripting languages for data analysis and visualization.
• Background in generating and screening high-diversity sequence libraries.
• Familiarity with laboratory automation and liquid handling systems.
• Experience with in-situ RNA sequencing and imaging (e.g., STARmap, Ribomap).

Culture & Benefits

• Competitive base salary and bonus potential.
• Generous early equity.
• Opportunity to contribute to the world's first scientific superintelligence platform.
• Interdisciplinary and collaborative work environment.