Principal Scientist, Target Discovery & Portfolio Strategy (AI)

Location: South San Francisco, California, United States

Base salary: $164,000–$205,000 annually, plus bonus and equity.

Company

hirify.global is a biotech startup using AI, generative models, and foundation models for biology to discover protein and antibody therapeutics for hard-to-drug targets.

What you will do

• Identify promising disease areas by assessing unmet needs, disease mechanisms, patient subsets, and limitations of current treatments.
• Prioritize therapeutic targets using human genetics, functional genomics, genome-scale multi-omics datasets, patient data, and clinical findings.
• Assess platform fit with molecular design, protein engineering, and functional screening teams.
• Evaluate target causality, modulation direction, safety risks, knowledge gaps, and therapeutic hypotheses.
• Develop target assessments covering disease rationale, patient selection, competition, differentiation, and risks.
• Track emerging science and competition, use AI tools to analyze multimodal data, and lead discovery programs or platform initiatives.

Requirements

• PhD in immunology or a related field.
• 6+ years of industry experience in drug discovery, target discovery, preclinical drug development, or translational drug development.
• Experience integrating human genetics, genome-scale multi-omics, human data, cell biology, disease biology, and clinical findings.
• Strong scientific judgment for distinguishing credible therapeutic opportunities from interesting associations.
• Clear communication skills and the ability to guide cross-disciplinary decisions.
• Curiosity, independence, and willingness to challenge assumptions as evidence evolves.

Culture & Benefits

• Open, flexible, and friendly work environment.
• Competitive base salary, bonus, and equity package.
• Benefits package and long-term career development support.
• Commitment to a diverse and inclusive workplace.