Sr. Scientist, Lentivirus Upstream Processing

Location: Hybrid role based in Somerset, New Jersey, United States

Salary: $127,313–$167,099 USD annual base pay, plus potential performance-based bonus and/or equity.

Company

hirify.global is a global biotechnology company developing cell therapy platforms, including CAR-T, CAR-NK, CAR-γδ T, and other emerging technologies.

What you will do

• Design and execute experimental strategies for lentiviral vector upstream production.
• Develop and optimize seed train expansion, HEK293/HEK293T mammalian cell culture, transient transfection, feeding strategies, and perfusion processes.
• Develop and validate bioreactor scale-up and scale-down models using stir-tank and rocker systems.
• Translate bench-scale processes to GMP manufacturing, support technology transfer, and troubleshoot clinical production runs.
• Optimize vector titer, specific productivity, and product quality while documenting process parameters and performance limits.
• Prepare development reports, SOPs, and regulatory submission content, and collaborate with CMC, downstream, analytical, and external CDMO teams.

Requirements

• Advanced degree, preferably PhD or MS, in Chemical Engineering, Bioengineering, or a related field.
• 5–8 years of experience with a PhD or 8+ years with an MS in biotech or pharmaceutical process development or manufacturing.
• Hands-on experience with HEK293/HEK293T culture, seed train expansion, feeding strategies, and viral-vector transient transfection optimization.
• Experience developing and implementing bioreactor scale-up and scale-down models, with knowledge of engineering modeling, mass transfer, and bioprocess optimization.
• Understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
• Applicants must be authorized to work in the United States; employment eligibility is verified through Form I-9 and E-Verify.

Nice to have

• Experience with lentiviral vector technologies and large-scale upstream bioreactor processes above 50L, including 200L or 500L systems.
• Mandarin language skills.

Culture & Benefits

• Hybrid work environment within a global biotechnology organization.
• Medical, dental, and vision insurance with a 401(k) plan and company match vesting fully on day one.
• Eight weeks of paid parental leave after three months of employment.
• Paid vacation, personal and sick time, floating holidays, and eleven company holidays.
• Additional health, disability, commuter, family-care, well-being, and recognition benefits are available to permanent full-time employees.