Front Line Manufacturing Manager (Bulk Drug Substance - Downstream) - Night Shift

Location: Holly Springs, North Carolina, United States. Onsite night shift with a 12-hour 2-2-3 schedule from 5:45 p.m. to 6:15 a.m.

Company

hirify.global is a biotechnology company developing and manufacturing medicines and operating an advanced drug substance manufacturing facility with disposable and stainless-steel technologies.

What you will do

• Lead manufacturing teams supporting 24/7 GMP drug substance production.
• Maintain a safe, compliant production environment, including cGMP, CFR, gowning, and aseptic technique requirements.
• Oversee manufacturing processes, equipment setup, execution, completion, and maintenance activities.
• Recruit, train, coach, evaluate, and mentor manufacturing associates.
• Identify improvement opportunities, lead change efforts, and optimize operating procedures.
• Develop CAPAs, resolve complex operational problems, and collaborate with QA/QC, facilities, planning, manufacturing, process development, and regulatory teams.

Requirements

• Doctorate degree; or master's degree with 3 years of manufacturing or operations experience; or bachelor's degree with 5 years; or associate's degree with 10 years; or high school diploma/GED with 12 years.
• Previous managerial experience directly managing people or leading teams, projects, programs, or resource allocation.
• Leadership and technical understanding of biotechnology production operations.
• Experience in a cGMP manufacturing facility, including 5+ years of process experience and 3+ years in an area lead, specialist, or manager role.
• Understanding of downstream purification operations, including column chromatography, TFF, viral filtration, and viral inactivation.
• Strong communication, analytical problem-solving, conflict-resolution, project-management, computer, Microsoft, EBR/MES, Delta V, and electronic quality systems skills.

Nice to have

• Bachelor's degree in life sciences or engineering.
• Experience with biotechnology or pharmaceutical plant startup.
• Experience with performance management, performance reviews, coaching, mentoring, and counseling.

Culture & Benefits

• Health, dental, vision, life, disability, and flexible spending benefits.
• Retirement and savings plan with company contributions.
• Discretionary annual bonus and stock-based long-term incentives.
• Paid time off and biannual company-wide shutdowns.
• Career development opportunities and flexible work models where applicable.