Scientist I/Scientist II, tLNP Formulation and Delivery (AI/Biology)

Location: Emeryville, California, United States. Applicants must have ongoing US work authorization that does not require employer sponsorship.

Hiring salary range: $132,000–$160,000 USD per year

Company

hirify.global is an AI lab for biology building foundation models for biological molecules and solutions for medicine and agriculture.

What you will do

• Design and execute targeted lipid nanoparticle formulations carrying nucleic acid payloads such as mRNA and sgRNA.
• Develop surface modifications and bioconjugation chemistries to attach antibodies, VHHs, nanobodies, and peptides to LNPs.
• Perform particle size, polydispersity, zeta potential, encapsulation efficiency, and degree-of-labeling analyses.
• Establish mammalian cell culture models and quantitative assays for target binding, cellular uptake, endosomal escape, and cargo translation.
• Design and analyze in vivo biodistribution, pharmacokinetic, and organ-targeting studies to establish structure-activity relationships.
• Maintain electronic lab records, prepare technical and patent disclosure materials, and present findings to scientific leadership.

Requirements

• Ph.D. in biomedical engineering, chemical engineering, pharmaceutical sciences, or a related field.
• Scientist I: 0–2 years of relevant experience; Scientist II: 2–4 years of relevant experience.
• Hands-on experience with LNP assembly platforms and nanoparticle surface bioconjugation.
• Experience with mammalian cell culture and quantitative assays such as flow cytometry/FACS, reporter assays, and ELISAs.
• Understanding of nanoparticle biodistribution, protein corona formation, vascular barriers, and in vivo study design.
• Legal authorization to work in the United States is required; visa sponsorship will not be provided.

Nice to have

• Experience with automated or high-throughput liquid-handling platforms.
• Knowledge of Design of Experiments software such as JMP.
• Experience with advanced nanoparticle characterization techniques including HPLC-SEC or UPLC-CAD.

Culture & Benefits

• High-growth environment focused on protein design, AI, and biology.
• Competitive compensation with equity participation.
• 401(k) with a strong employer match.
• Health, dental, and vision insurance.
• Generous paid time off, work-life balance, and professional development opportunities.