Senior Scientist / Scientist, In Vivo Pharmacology (Biotech)

Location: South San Francisco, United States

Salary: $130,000–$180,000 per year

Company

hirify.global is a biotechnology company developing medicines for age-related diseases by reprogramming the epigenome and restoring regenerative potential in aged and diseased cells.

What you will do

• Design, execute, and interpret in vivo pharmacology studies covering PK/PD, efficacy, and dose-response across disease models and therapeutic programs.
• Evaluate epigenetic reprogramming payloads in relevant animal models with epigenetic editing, predictive modeling, and therapeutic area teams.
• Develop and refine animal models of aging and age-related disease for translational studies.
• Oversee study design, protocols, and CRO or vendor relationships.
• Analyze pharmacology data, biomarkers, and functional endpoints to guide preclinical decisions.
• Contribute to regulatory-enabling study design and documentation as programs advance toward clinical development.

Requirements

• Ph.D. in pharmacology, physiology, biology, or a related field, or equivalent industry experience.
• 5+ years of experience for Scientist or 8+ years for Senior Scientist.
• Demonstrated experience designing and executing in vivo pharmacology studies in rodent models, including PK, PD, efficacy, and dose-range finding.
• Experience with study design, dosing regimens, route-of-administration selection, and in vivo data interpretation.
• Experience leading project workflows and mentoring junior laboratory staff.
• Experience contributing to a preclinical or clinical drug development program.

Nice to have

• Experience with liver biology, hepatic disease models, or hepatocyte-directed delivery.
• Experience with nucleic acid or viral vector delivery in vivo.
• Experience with GLP-enabling or IND-enabling study design.
• Experience with single-cell genomics or pooled screening approaches applied to in vivo readouts.

Culture & Benefits

• Health, dental, and vision insurance.
• 401(k) with company match.
• Paid parental leave.
• 20 days of paid time off per year plus holidays.
• Meals and snacks provided on site.