8 дней назад
Scientist, In Vivo High Throughput Screening & Analytics
133 195 - 172 370$
Мэтч & Сопровод
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Описание вакансии
Текст:
TL;DR
Scientist, In Vivo High Throughput Screening & Analytics (biotechnology and cell/gene therapy): Designing and executing high-throughput screening, automated assay, vector characterization, and data analysis workflows for in vivo lentiviral vector research with an accent on reproducibility, analytical rigor, and cross-functional scientific decision-making. Focus on optimizing liquid-handling workflows, interpreting complex cell- and vector-based assay data, and solving automation, assay variability, and data integrity challenges.
Location: Philadelphia, Pennsylvania, United States
Salary: $133,195–$172,370 per year, plus potential annual bonus, stock-based long-term incentives, paid time off, and benefits.
Company
is a biopharmaceutical company developing cancer immunotherapies, including CAR T-cell and T-cell receptor engineered therapies.
What you will do
- Design, plan, and execute high-throughput screening, miniaturized, scale-down, and analytical experiments for lentiviral vector research.
- Develop, optimize, and troubleshoot automated and semi-automated laboratory workflows using liquid handling, scheduling, plate-based assay, and data capture platforms.
- Execute and analyze mammalian cell-, vector-, and analytical assays covering transduction, binding, expression, potency, and vector performance.
- Build data reduction, visualization, quality control, and reporting workflows using tools such as Python, R, SQL, VBA, JMP, Prism, and Spotfire.
- Interpret complex experimental data, recommend evidence-based next steps, and communicate findings through technical reports, presentations, and data packages.
- Collaborate with Discovery, Process Development, Analytical Development, and other research functions while maintaining traceable records and training colleagues.
Requirements
- MS with 4+ years of relevant experience, BS with 6+ years, or PhD/PharmD in a relevant scientific discipline with applicable experience.
- Advanced knowledge of biotechnology, molecular biology, cell biology, immunology, biomedical engineering, analytical development, or a related field.
- Experience with high-throughput screening, assay miniaturization, laboratory automation, automated liquid handling, or scale-down systems.
- Hands-on experience with mammalian cell culture, plate-based assays, vector or cell-based characterization, and analytical method development.
- Ability to independently design experiments, troubleshoot methods, analyze complex data, define next steps, and communicate scientific findings.
- Strong documentation, data quality, laboratory safety, reproducibility, collaboration, and mentoring skills.
Nice to have
- Experience with lentiviral vector production, primary immune cell or T-cell assays, transduction, flow cytometry, ELISA/AlphaLISA, BLI/Octet, internalization, or potency assays.
- Experience with Tecan, Hamilton, Beckman Biomek, CyBio FeliX, Opentrons, or comparable laboratory automation platforms.
- Programming or scripting experience in Python, R, SQL, VBA, MATLAB, or related tools.
- Familiarity with Design of Experiments, multivariate optimization, assay qualification, and statistical methods.
Culture & Benefits
- Full-time employment within a cross-functional cancer immunotherapy research organization.
- Medical, dental, vision, and life insurance plans.
- Paid time off and potential discretionary annual bonus.
- Potential eligibility for discretionary stock-based long-term incentives.
- Inclusive environment focused on employee development, collaboration, and scientific impact.
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