Scientist (Biotechnology)

Location: Onsite in Cambridge, Massachusetts, United States

Salary: $123,300–$150,700 USD per year, plus performance-based annual cash bonus, new hire equity grant, and potential annual equity awards.

Company

hirify.global develops curative genome editing treatments for severe and life-threatening diseases.

What you will do

• Design and execute discovery proteomics workflows, including sample preparation, LC-MS/MS acquisition, and downstream bioinformatic analysis.
• Develop immunopeptidomics workflows covering MHC class I/II immunoaffinity purification, peptide processing, and nanoflow LC-MS/MS.
• Analyze complex proteomics and immunopeptidomics datasets using specialized search software and bioinformatic tools.
• Apply top-down and native mass spectrometry to characterize protein structure, complex integrity, and post-translational modifications when relevant.
• Select and optimize separation chemistry and mass spectrometry platforms for specific analytes and biological questions.
• Lead assay development and discovery projects, author methods and SOPs, and communicate findings with immunology, process development, and other cross-functional groups.

Requirements

• Hands-on experience with immunopeptidomics, including MHC/HLA immunoprecipitation and low-abundance peptide LC-MS/MS.
• Experience with native and/or intact protein mass spectrometry and a strong bioanalytical or structural mass spectrometry background.
• Familiarity with HLA-binding prediction tools and immunopeptidomics-specific proteomics search software.
• PhD in a biological or relevant technical/engineering field, or equivalent experience; typically 0–3+ years post-PhD, 6–9+ years with an MS, or 8–11+ years with a BS.
• Ability to manage study timelines, ensure data quality, interpret experimental results, and apply conclusions to new experiments.
• Ability to lift up to 15 pounds occasionally and work for prolonged periods at a desk and computer.

Nice to have

• Top-down or native protein mass spectrometry expertise.

Culture & Benefits

• Mission focused on developing genome editing treatments that can transform patients’ lives.
• Performance-based annual cash bonus.
• New hire equity grant and eligibility for annual equity awards.
• Salary reviewed periodically based on role, performance, and business factors.
• Fast-paced, deadline-driven scientific environment with cross-functional collaboration.