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8 дней назад

Scientist / Associate Scientist – Preclinical Design & Development (PDD) Core

86 320 - 154 960$
Формат работы
onsite
Тип работы
fulltime
Английский
b2
Страна
US
Вакансия из списка Hirify.GlobalВакансия из Hirify Global, списка международных tech-компаний
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Описание вакансии

Текст:
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TL;DR
Scientist / Associate Scientist – Preclinical Design & Development (PDD) Core (RNA Biology/Precision Genomics): Designing and executing cellular workflows to evaluate mutation-specific antisense therapies using patient-derived models, quantitative molecular assays, and biochemical and imaging readouts with an accent on pre-mRNA splicing, high-throughput screening, and translational rigor. Focus on deriving and banking patient-specific cells, validating RT-qPCR and ddPCR assays, and coordinating parallel experiments across ultra-rare genetic disease cases.

Location: Memphis, TN, United States

Salary: $86,320–$154,960 per year for the Scientist / Associate Scientist role. An Associate Scientist range of $65,520–$114,400 is also listed.

Company

hirify.global is a leading research institution advancing pediatric translational neuroscience and therapies for rare genetic conditions.

What you will do

  • Design and execute cell-based therapeutic evaluation workflows and validation pipelines across concurrent patient cases.
  • Derive, characterize, and bank patient-specific cellular models for screening and functional validation.
  • Design and validate RT-qPCR and ddPCR assays and perform biochemical and imaging-based readouts.
  • Manage parallel experimental timelines and communicate proactively with collaborating teams.
  • Maintain documentation, data integrity, quality control, supplies, and laboratory equipment.
  • Support a collaborative, shared-responsibility research environment.

Requirements

  • Bachelor's degree in genomics, molecular biology, cell biology, or a related scientific field.
  • Experience with plate-based molecular screening workflows and quantitative nucleic acid assays, including RT-qPCR and ddPCR.
  • Working knowledge of RNA biology, particularly pre-mRNA splicing, and ability to interpret molecular readouts in a therapeutic context.
  • Proficiency in mammalian cell culture, including complex or patient-derived cellular models.
  • Ability to execute multi-step workflows across parallel projects and adapt protocols under scientific uncertainty.
  • Relevant research experience: 8 years for Scientist, or 7+ years for Associate Scientist, with reduced requirements for candidates holding a Master's degree or PhD.

Nice to have

  • Experience with isoform-discriminating or allele-specific probe design.
  • Prior experience with Janus liquid handlers.

Culture & Benefits

  • Team-based, project-driven translational research environment.
  • Work focused on mutation-specific antisense therapies for ultra-rare and n-of-1 genetic conditions.
  • Benefits are provided through hirify.global.
  • Human-centered hiring process with human review and engagement alongside supporting technology.

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