8 дней назад
Scientist / Associate Scientist – Preclinical Design & Development (PDD) Core
86 320 - 154 960$
Мэтч & Сопровод
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Описание вакансии
Текст:
TL;DR
Scientist / Associate Scientist – Preclinical Design & Development (PDD) Core (RNA Biology/Precision Genomics): Designing and executing cellular workflows to evaluate mutation-specific antisense therapies using patient-derived models, quantitative molecular assays, and biochemical and imaging readouts with an accent on pre-mRNA splicing, high-throughput screening, and translational rigor. Focus on deriving and banking patient-specific cells, validating RT-qPCR and ddPCR assays, and coordinating parallel experiments across ultra-rare genetic disease cases.
Location: Memphis, TN, United States
Salary: $86,320–$154,960 per year for the Scientist / Associate Scientist role. An Associate Scientist range of $65,520–$114,400 is also listed.
Company
is a leading research institution advancing pediatric translational neuroscience and therapies for rare genetic conditions.
What you will do
- Design and execute cell-based therapeutic evaluation workflows and validation pipelines across concurrent patient cases.
- Derive, characterize, and bank patient-specific cellular models for screening and functional validation.
- Design and validate RT-qPCR and ddPCR assays and perform biochemical and imaging-based readouts.
- Manage parallel experimental timelines and communicate proactively with collaborating teams.
- Maintain documentation, data integrity, quality control, supplies, and laboratory equipment.
- Support a collaborative, shared-responsibility research environment.
Requirements
- Bachelor's degree in genomics, molecular biology, cell biology, or a related scientific field.
- Experience with plate-based molecular screening workflows and quantitative nucleic acid assays, including RT-qPCR and ddPCR.
- Working knowledge of RNA biology, particularly pre-mRNA splicing, and ability to interpret molecular readouts in a therapeutic context.
- Proficiency in mammalian cell culture, including complex or patient-derived cellular models.
- Ability to execute multi-step workflows across parallel projects and adapt protocols under scientific uncertainty.
- Relevant research experience: 8 years for Scientist, or 7+ years for Associate Scientist, with reduced requirements for candidates holding a Master's degree or PhD.
Nice to have
- Experience with isoform-discriminating or allele-specific probe design.
- Prior experience with Janus liquid handlers.
Culture & Benefits
- Team-based, project-driven translational research environment.
- Work focused on mutation-specific antisense therapies for ultra-rare and n-of-1 genetic conditions.
- Benefits are provided through .
- Human-centered hiring process with human review and engagement alongside supporting technology.
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