Principal Scientist, Immunogenicity and Ligand Binding Assays (mRNA-LNP)

Location: Oxford, England, United Kingdom; hirify.global follows a 70/30 work model with 70% in-office collaboration.

Company

hirify.global develops mRNA medicines through its mRNA technology platform and therapeutic pipeline.

What you will do

• Provide scientific and hands-on oversight of ligand binding assay bioanalysis for mRNA-LNP therapeutic development programs.
• Design and execute phase-appropriate, risk-based clinical bioanalytical strategies across clinical development stages.
• Lead regulated development, validation, and clinical sample testing for anti-drug antibody and neutralizing antibody assays.
• Drive development and implementation of cell-based assays, immunoassays, translated-protein quantitation, PK assays, and PD assays.
• Review analytical data, validation results, and study reports to ensure scientific integrity, data quality, and regulatory compliance.
• Collaborate with internal and external stakeholders, contribute to regulatory submissions, and support responses to regulatory authorities.

Requirements

• Ph.D. in infectious disease, immuno-oncology, immunology, cancer biology, or a related field, plus 10+ years of industry biotechnology or pharmaceutical experience; an M.S. with extensive bioanalytical experience may be considered.
• Experience with clinical assay platforms including ECL, Gyrolab, reporter gene assays, DELFIA assays, and related methodologies.
• Knowledge of GLP requirements, regulatory expectations, and current bioanalytical industry practices.
• Ability to communicate scientific concepts, program objectives, and data analysis in a matrix environment.
• Experience with RNA, biologics, and cell therapy is preferred.
• Experience with Watson LIMS and LabVantage eLBN is advantageous.

Culture & Benefits

• In-person collaboration model emphasizing innovation, teamwork, and direct mentorship.
• Healthcare coverage and voluntary benefit programs.
• Fitness, mindfulness, and mental health support.
• Family-building benefits, including fertility, adoption, and surrogacy support.
• Paid vacation, bank holidays, volunteer days, sabbatical, global recharge days, and year-end shutdown.
• Savings and investment programs, with additional location-specific benefits.