Senior Scientist, In Vivo Pharmacology

Location: Fully onsite in Cambridge, Massachusetts, United States, with occasional weekend work.

Salary: $127,500–$170,000 per year.

Company

Biotechnology organization developing pharmaceutical therapies for rare diseases, manufactured transplantable organs, and machine learning-driven iPSC-derived thymic cell therapies.

What you will do

• Design, execute, and interpret in vivo studies evaluating the efficacy, safety, pharmacology, biodistribution, persistence, and mechanism of action of iPSC-derived thymic cell products.
• Develop and refine mouse models for immune reconstitution, immunosenescence, aging, and immune tolerance.
• Investigate thymic regeneration, T-cell development, immune tolerance, and immunosenescence using cellular and molecular approaches.
• Implement high-dimensional immune profiling, including flow cytometry, RNA sequencing, and functional immunological assays, and develop translational biomarker strategies.
• Generate robust proof-of-concept, pharmacology, and mechanism-of-action data packages to support candidate selection and nonclinical development.
• Collaborate with research, process development, analytical development, regulatory, project, and leadership teams; communicate results and mentor junior scientists.

Requirements

• PhD in immunology, stem cell biology, regenerative medicine, or a related discipline.
• 5+ years of experience developing preclinical models and independently designing and executing in vivo mouse studies.
• Strong knowledge of immunology, thymus biology, T-cell development, immune reconstitution, and immune tolerance.
• Hands-on expertise in rodent handling, tissue collection and dissection, multiple administration routes, and primary human and murine cell and tissue culture.
• Experience with immunological assays, multicolor flow cytometry, qPCR or ddPCR, histology, ELISA/MSD, statistical analysis, and experimental troubleshooting.
• Excellent communication skills and the ability to work effectively in a fast-paced, collaborative biotech environment.

Nice to have

• Experience with nonclinical development, IND-enabling studies, regulatory authoring, proof-of-concept, pharmacology, mechanism-of-action, or translational studies.
• Knowledge of immunosenescence, age-related immune dysfunction, tumor immunology, autoimmunity, and transplantation immunology or tolerance.
• Scientific publications or intellectual property contributions.

Culture & Benefits

• Mission-driven work focused on unmet medical needs and life-threatening diseases.
• Medical, dental, vision, prescription, wellness, disability, and savings plan benefits.
• 401(k), employee stock purchase plan, paid time off, and paid parental leave.
• Collaborative, rigorous, and fast-paced biotechnology environment.