Senior DMPK Director

Location: Alameda, California, United States; office-based

Salary: $183,000–$260,000 annually, plus bonus eligibility and equity incentives.

Company

hirify.global is a biopharmaceutical company developing drug candidates and advancing them through clinical development and regulatory registration.

What you will do

• Lead translational IND- and NDA-enabling ADME work and characterize the ADME properties of drug candidates.
• Develop DMPK and modeling and simulation strategies across discovery and development programs.
• Analyze preclinical pharmacokinetic and pharmacodynamic data to support drug development decisions.
• Partner with Discovery, Clinical Pharmacology, Pharmacometrics, Translational Medicine, CMC, Toxicology, Clinical Development, and Regulatory functions.
• Prepare DMPK content for IND, CTA, and NDA filings, study protocols, study reports, and investigator brochures.
• Present scientific findings to senior management, project teams, and internal and external collaborators while maintaining external scientific visibility through publications.

Requirements

• PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a related field.
• At least 12 years of DMPK experience and a minimum of 14 years of relevant pharmaceutical-industry experience.
• Expert knowledge of in vitro and in vivo ADME studies, drug metabolism, transporters, enzymology, enzyme kinetics, and in vitro to in vivo extrapolation.
• Experience managing external DMPK work at CROs and identifying clinical candidates by balancing ADME, pharmacology, and toxicology properties.
• Experience with physiologically based and empirical modeling and simulation techniques, including drug-drug interactions and biopharmaceutics liabilities.
• Experience submitting IND, NDA, BLA, and global marketing applications, with strong scientific leadership and cross-functional collaboration skills.

Nice to have

• Experience with antibody-drug conjugates.

Culture & Benefits

• Collaborative, modern open-plan office with dual monitors and ergonomic workstations.
• Health, dental, and vision coverage, life and disability insurance, flexible spending accounts, and a 401(k) plan with company contributions.
• Discretionary annual bonus program and opportunities to purchase company stock and receive long-term incentives.
• 15 accrued vacation days in the first year, 17 paid holidays including a company-wide winter shutdown, and up to 10 sick days annually.
• Science-driven environment focused on innovation, teamwork, agility, transparency, accountability, and empowerment.