Computational Genomics Senior Research Scientist (AI)

Location: San Diego, California, United States; hybrid work with at least three days per week on-site, or on-site work five days per week with ad hoc flexibility.

Base salary: $129,900–$194,900 per year, plus eligibility for an annual bonus and annual equity awards.

Company

Vertex is a global biotechnology company focused on scientific innovation and the development of transformative therapies for serious human diseases.

What you will do

• Partner with cross-functional disease project teams to identify questions addressable through human genetics, genomics, sequencing, and computational analysis.
• Design, execute, and interpret human genetic, genomic, and multi-omic studies for target discovery, target validation, biomarker development, and mechanistic understanding.
• Develop and apply computational and statistical methods to complex biological datasets, integrating internal and public resources.
• Own analyses from biological question through actionable recommendation and communicate conclusions, limitations, and next steps to scientific audiences.
• Shape genomics strategies across discovery programs and ensure rigorous study design, analysis plans, and interpretation.
• Collaborate with computational and experimental scientists to apply machine learning and AI technologies to genomic and human genetic data.

Requirements

• PhD in computational biology, bioinformatics, genomics, human genetics, systems biology, bioengineering, or a related field with 3+ years of relevant postdoctoral or industry experience; alternatively, a related Master's degree with 8+ years of relevant industry experience.
• Demonstrated expertise in analyzing, visualizing, and interpreting human genetics, genomic, and next-generation sequencing data.
• Experience applying computational methods and bioinformatics tools to large-scale biological datasets.
• Proficiency in R, Python, Unix/Linux environments, and high-performance computing systems.
• Strong foundation in statistics and genetics, including human genetic variation in disease biology.
• Ability to independently drive scientific questions from study design through interpretation and influence project decisions.

Culture & Benefits

• Collaborative, cross-functional scientific environment spanning disease biology, experimental genomics, translational research, computational sciences, and project leadership.
• Medical, dental, and vision benefits with paid time off, including week-long summer and winter company shutdowns.
• Educational assistance programs, including student loan repayment.
• Commuting subsidy, matching charitable donations, and 401(k).
• Hybrid or on-site work flexibility under the Flex @ Vertex program.