Principal Scientist - Small Molecule LC-MS/MS

Location: Merthyr Tydfil, United Kingdom

Company

hirify.global is a full-service contract research organization providing clinical development solutions for small and mid-size drug developers, with expertise in clinical pharmacology, oncology, and rare diseases.

What you will do

• Lead small molecule LC-MS/MS method development and validation, from extraction strategy through to fully validated assays.
• Troubleshoot instrument, extraction, chromatographic, and method issues as the team’s technical escalation point.
• Take scientific accountability for assigned studies, including data integrity, regulatory compliance, timelines, and final reporting.
• Review and approve protocols, validation reports, SOPs, and other study documentation.
• Mentor scientists in LC-MS/MS techniques and provide technical direction on method strategy.
• Represent Laboratory Services with clients, sponsors, auditors, and inspectors, while supporting Business Development with technical input.

Requirements

• Extensive hands-on LC-MS/MS experience using triple quadrupole platforms in a regulated laboratory environment, such as GCP, GLP, and/or GMP.
• Proven experience leading small molecule bioanalytical method development and validation.
• Strong knowledge of protein precipitation, liquid-liquid extraction, solid-phase extraction, and chromatographic troubleshooting.
• Working knowledge of current bioanalytical method validation guidance.
• Ability to review and approve technical documentation to GxP standards.
• Experience managing study timelines and priorities under deadline pressure.

Nice to have

• MSc or PhD in a relevant scientific discipline.
• CRO or clinical trial experience.
• Familiarity with MHRA Phase I Accreditation requirements.
• Six Sigma, Lean, or project management certification.
• Experience supporting audits and regulatory inspections, plus mentoring or informal line management experience.

Culture & Benefits

• Work alongside multidisciplinary experts in clinical development and laboratory services.
• Exposure to innovative medicines for serious unmet medical needs.
• Opportunity to contribute to oncology, rare disease, and clinical pharmacology programs.
• Work in a growing CRO focused on tailored and scalable clinical development solutions.