Principal Scientist - Small Molecule LC-MS/MS

Location: Merthyr Tydfil, United Kingdom

Company

hirify.global is a full-service CRO providing clinical development solutions for small and mid-size drug developers, with expertise in clinical pharmacology, oncology, and rare diseases.

What you will do

• Lead small-molecule LC-MS/MS method development and validation from extraction strategy through fully validated assays.
• Troubleshoot instrument, extraction, chromatographic, and method issues as the team’s technical escalation point.
• Own assigned studies, including data integrity, regulatory compliance, protocols, validation reports, SOPs, documentation, and final reporting.
• Mentor scientists developing their LC-MS/MS technique.
• Represent Laboratory Services with clients, auditors, and sponsors, and provide technical input to Business Development.

Requirements

• Extensive hands-on LC-MS/MS experience using triple quadrupole platforms in a regulated laboratory environment under GCP, GLP, and/or GMP.
• Proven experience leading small-molecule bioanalytical method development and validation.
• Strong knowledge of protein precipitation, liquid-liquid extraction, solid-phase extraction, and chromatographic troubleshooting.
• Working knowledge of current bioanalytical method validation guidance.
• Ability to review and approve technical documentation to GxP standards.
• Experience managing study timelines and priorities under deadline pressure.

Nice to have

• MSc or PhD in a relevant scientific discipline.
• CRO or clinical trial experience.
• Familiarity with MHRA Phase I Accreditation requirements.
• Six Sigma, Lean, or project management certification.
• Experience supporting audits and regulatory inspections.
• Mentoring or informal line management experience.

Culture & Benefits

• Work alongside experts from multiple clinical development and laboratory disciplines.
• Exposure to innovative medicines in rare disease, oncology, and clinical pharmacology.
• Opportunity to contribute to studies addressing serious unmet medical needs.
• Hands-on scientific ownership within a growing CRO.