Scientist 3, Neuro iPSC Disease Modeling Group / Stem Cell Neurobiology (iPSC)

Location: South San Francisco, California, United States

Salary: $103,400–$192,000 per year, plus a potential discretionary annual bonus

Company

hirify.global is a biotechnology company and Roche group member focused on discovering and developing medicines for serious and life-threatening diseases.

What you will do

• Design and optimize differentiation protocols for human iPSC-derived CNS cell types, including neurons, microglia, astrocytes, and oligodendrocytes.
• Use CRISPR/Cas9 and cellular engineering to create disease-relevant mutants, reporter lines, and knockout models.
• Develop co-culture and 3D cellular models to study complex neurodegenerative disease phenotypes.
• Establish molecular and functional assays using qPCR, RNA-seq, proteomics, immunostaining, high-content imaging, and flow cytometry.
• Lead arrayed or pooled functional CRISPR screens to identify disease modifiers and therapeutic targets.
• Analyze cellular, genetic, and functional datasets and communicate findings through reports and scientific presentations.

Requirements

• Ph.D. in Stem Cell Biology, Molecular Biology, Neuroscience, Immunology, or a related scientific discipline.
• 0–3 years of research experience in academia, biotechnology, or pharmaceuticals.
• Hands-on expertise in human iPSC culture, quality control, genetic engineering, and directed differentiation into CNS cell types.
• Experience with CRISPR-based genetic perturbation and functional screening workflows.
• Strong background in optical imaging, molecular profiling, biochemistry, and quantitative cellular assays.
• Proactive approach, clear communication, data integrity, and collaborative teamwork.

Nice to have

• Experience with multicellular co-culture models and disease-relevant functional assays such as protein misfolding and aggregation assays.
• Experience with non-viral delivery methods such as LNPs or viral vectors including lentivirus and AAV.
• Experience with automated liquid handlers, high-throughput screening, or single-cell sequencing analysis using R or Python.
• Familiarity with AI or machine learning-based image analysis for cellular phenotyping.
• Pharmaceutical industry experience.

Culture & Benefits

• Collaborative, cross-functional, and fast-paced research environment.
• Opportunity to contribute to neuroscience research, drug discovery, and therapeutic pipeline advancement.
• Regular employment with company benefits.
• Relocation benefits are available.