Scientist II, Arrayed Screening (Drug Discovery)

Location: South San Francisco, California; onsite 5 days per week

Salary: $136,000–$145,000 per year for successful US-based applicants, plus annual performance bonus and equity incentive eligibility.

Company

hirify.global is a drug discovery and development company using machine learning and large-scale multimodal biological data to develop predictive disease models and transformative medicines.

What you will do

• Develop, optimize, and execute arrayed screening assays in 96- and 384-well plate formats using endpoint, kinetic, imaging-based, and biochemical readouts.
• Design cell-based screening workflows using immortalized, primary, iPSC-derived, and engineered cellular models.
• Support small-molecule, genetic, and perturbational screening, including assay development, target validation, mechanism-of-action studies, and screening campaigns.
• Partner with automation and process engineering teams to scale assays using liquid handlers and platforms such as Echo, Hamilton, Bravo, and Tecan.
• Analyze assay and screening data, troubleshoot performance, identify trends, and communicate results to multidisciplinary project teams.
• Collaborate with biology, engineering, data science, machine learning, genetics, and drug discovery teams to generate reproducible, well-annotated datasets and maintain rigorous documentation in Benchling and LIMS.

Requirements

• PhD in cell biology, molecular biology, biochemistry, pharmacology, bioengineering, chemical biology, or a related field, plus 2–5 years of relevant post-PhD or equivalent industry experience.
• Strong hands-on experience developing and running cell-based assays in high-throughput plate formats.
• Experience with quantitative cellular readouts such as high-content imaging, fluorescence or luminescence assays, viability assays, reporter assays, immunostaining, or flow cytometry.
• Strong mammalian cell culture skills, including aseptic technique and work with immortalized, primary, stem-cell-derived, or engineered cell systems.
• Familiarity with cloning, CRISPR or gene editing, transgene expression, stable cell line generation, qPCR, or related molecular biology methods.
• Ability to analyze and clearly communicate complex biological datasets; experience with GraphPad Prism, Spotfire, Benchling, Python, or R.

Nice to have

• Experience with screening automation and liquid-handling platforms.
• Biotech or pharma high-throughput screening experience and phenotypic assays for disease-relevant human cell models.
• Experience generating datasets for machine learning, image analysis, or quantitative modeling.
• Familiarity with assay miniaturization, automation troubleshooting, Z-factor metrics, dose-response analysis, or screening data quality control.
• Experience in neuroscience, metabolic disease, oncology, immunology, or rare disease.

Culture & Benefits

• 401(k) plan with employer matching.
• Medical, dental, vision, mental health, and well-being coverage.
• Open vacation policy and paid parental leave of at least 16 weeks for birthing parents and 10 weeks for other new parents.
• Quarterly budget for books and online courses, plus a home-office setup stipend.
• Monthly cell phone and internet stipend, free onsite baristas, and daily lunch for onsite employees.
• Free commuter bus service to and from the South San Francisco headquarters across the Bay Area.