Oligonucleotide Drug Bioinformatics Engineer (Bioinformatics)

TL;DR

Oligonucleotide Drug Bioinformatics Engineer (Bioinformatics): Designing small nucleic acid drugs (siRNA, ASO) with an accent on sequence design, off-target evaluation, and NGS data analysis. Focus on developing machine learning platforms for oligo design and constructing knowledge bases from public genomic databases.

Location: On-site in Natick, MA, USA

Company

hirify.global is a global pharmaceutical, biopharmaceutical, and medical device open-access capability and technology platform company.

What you will do

• Design small nucleic acid drugs (siRNA, ASO) using bioinformatics tools and ML platforms.
• Conduct off-target evaluations and analyze high-throughput NGS data, including preprocessing, QC, and alignment.
• Build internal knowledge bases by mining data from public databases like NCBI, Ensembl, and UniProt.
• Collaborate with wet lab, chemistry, and in vivo teams to refine bioinformatics models and workflows.
• Optimize existing design algorithms and create new chemical modification workflows for oligo drugs.

Requirements

• PhD in bioinformatics, computational biology, computer science, or related fields.
• 5+ years of experience in bioinformatics analysis or nucleic acid drug development.
• Proficiency in Python or R and strong experience with Linux systems.
• Expertise in bioinformatics tools such as BLAST, Bowtie, SAMtools, DESeq2, and STAR.
• Bilingual proficiency in English and Chinese as working languages.

Nice to have

• Experience applying AI and machine learning in bioinformatics.
• Proficiency in cloud computing for bioinformatics analysis.
• CADD-related software skills (e.g., RDkit, Schrodinger).
• Experience in multi-omics analysis.
• Additional programming skills in Perl or C.