Scientist (Biotech)

TL;DR

Scientist (Biotech): Researching and developing the next generation of cell therapies using in-vivo delivery technologies with an accent on in-vivo CAR and the treatment of cancer and autoimmune diseases. Focus on designing research experiments, optimizing lentivirus delivery, and executing complex in-vitro and in-vivo assays.

Location: Onsite in Philadelphia, PA

Salary: $96,267 - $126,351 USD

Company

A global biotechnology company dedicated to treating life-threatening diseases through advanced cell therapies and innovative immunotherapies.

What you will do

• Design and optimize research for next-generation cell therapies using in-vivo CAR-T.
• Isolate immune cells and execute evaluation of in-vivo CAR viruses using in-vitro assays and in-vivo mice models.
• Perform solid tumor research utilizing cell culture, transfection, FACS, and cell-based functional assays.
• Package, titer, and characterize engineered viruses using protein and PCR-based assays.
• Manage critical research data via ELN and present findings to internal groups and forums.
• Maintain strict compliance with GLP and EHS protocols.

Requirements

• PhD in Immunology or a related discipline.
• At least 2 years of experience in cell and gene therapy (in-vivo CAR-T experience preferred).
• Extensive experience in immune cell-based analytics, including multi-parameter flow-cytometry and cytotoxicity assays.
• Experience with lentivirus particle characterization and quantification (VCN and flow-based).
• Proficiency in advanced gene delivery methods using LVV, VLP, or LNP technologies.
• Proven track record of productivity evidenced by publications or patents.

Nice to have

• Experience with solid tumor models and in-vivo cell-specific gene delivery.
• Deep understanding of solid tumor models.

Culture & Benefits

• Comprehensive medical, dental, and vision insurance.
• 401(k) retirement plan with company match that vests fully on day one.
• 8 weeks of paid parental leave after 3 months of employment.
• Generous paid time off policy including vacation, personal, sick time, and 11 company holidays.
• Additional benefits including FSA, HSA, life insurance, and disability coverage.
• Well-being initiatives, peer-to-peer recognition, and family planning resources.