Scientist (Cell Therapy)

Location: Onsite in Philadelphia, Pennsylvania, United States

Base pay: $96,267–$126,351 USD per year, plus performance-based bonus and/or equity for eligible roles.

Company

Global biotechnology company developing cell and gene therapies, including CAR-T, TCR-T, NK-cell, and in-vivo cell therapy platforms for cancer and autoimmune diseases.

What you will do

• Design and optimize research studies for next-generation in-vivo CAR-T and cell therapy approaches.
• Identify novel solutions to in-vivo cell therapy challenges through literature analysis and project formation.
• Isolate immune cells from donor or patient blood and evaluate engineered CAR viruses using in-vitro assays and in-vivo mouse models.
• Perform cell culture, transfection, flow cytometry, and cell-based functional assays for solid-tumor research.
• Package, titer, and characterize engineered viruses using protein, PCR, flow-based, and vector-copy-number assays.
• Manage research data in an organized manner, present findings to internal and external audiences, and maintain GLP and EHS compliance.

Requirements

• PhD in immunology or a related discipline.
• At least 2 years of experience in cell and gene therapy; in-vivo CAR-T experience is preferred.
• Advanced experience with immune-cell analytics, multiparameter flow cytometry, cytotoxicity assays, and cytokine-release ELISA/MSD multiplex assays.
• Experience with lentivirus production, titration, transduction, and particle characterization using molecular and flow-based assays.
• Knowledge of immunology, immunotherapy, molecular biology, cellular biology, modified viral vectors, and gene-delivery technologies such as LVV, VLP, or LNP.
• Applicants must be authorized to work in the United States; employment eligibility is verified through Form I-9 and E-Verify.

Nice to have

• Experience with solid-tumor models and in-vivo cell-specific gene delivery.
• Publications or patents demonstrating research productivity.
• Deep understanding of solid-tumor models.

Culture & Benefits

• Collaborative, fast-paced biotechnology research environment with independent project ownership.
• Medical, dental, and vision insurance and a 401(k) plan with company match.
• Eight weeks of paid parental leave after three months of employment.
• Paid vacation, personal and sick time, floating holidays, and company holidays.
• Additional disability, life, legal, commuter, family-care, wellness, and flexible spending benefits.
• Benefits are available exclusively to permanent full-time employees; contractors are not eligible.