Sr. Scientist (Cell Therapy)

Location: Philadelphia, Pennsylvania, United States; onsite. Applicants must be authorized to work in the United States.

Salary: $127,313–$167,099 USD per year, plus potential performance-based bonus and/or equity.

Company

hirify.global is a biotechnology company developing cell and gene therapies, including CAR-T, TCR-T, NK cell-based therapies, and in-vivo delivery platforms.

What you will do

• Lead, design, and optimize research projects focused on next-generation in-vivo CAR-T therapies.
• Identify novel solutions for in-vivo cell therapy challenges through literature analysis and project formation.
• Isolate immune cells from healthy donors or patients and evaluate in-vivo CAR viruses using in-vitro assays and mouse models.
• Conduct solid-tumor research using cell culture, transfection, flow cytometry, and cell-based functional assays.
• Produce and characterize engineered viruses, measuring transduction rates through flow-based and vector copy number analyses.
• Manage critical research data, present results to internal and external audiences, and maintain GLP and EHS compliance.

Requirements

• PhD in immunology or a related discipline.
• At least 4 years of experience in cell and gene therapy; in-vivo CAR-T experience is preferred.
• Advanced experience in immune-cell analytics, multiparameter flow cytometry, cytotoxicity assays, and cytokine-release ELISA/MSD multiplex assays.
• Experience with lentivirus production, titration, particle characterization, transduction, and molecular or flow-based quantification.
• Proficiency in gene-delivery technologies including LVV, VLP, or LNP, with working knowledge of modified viral-vector design and evaluation.
• Strong immunology, immunotherapy, molecular biology, cellular biology, communication, multitasking, and problem-solving skills.

Nice to have

• Experience with solid-tumor models and in-vivo cell-specific gene delivery.
• Publications or patents demonstrating research productivity.
• Deep understanding of solid-tumor models.

Culture & Benefits

• Collaborative, fast-paced biotech environment with opportunities to advance multiple discovery projects.
• Medical, dental, and vision insurance.
• 401(k) retirement plan with company match vesting fully on day one.
• Eight weeks of paid parental leave after three months of employment.
• Paid vacation, personal time, sick time, floating holidays, and eleven company holidays.
• Additional flexible spending, health savings, disability, commuter, family-care, and well-being benefits for permanent full-time employees.