2 months ago
Immunology Senior Research Scientist (Spatial Transcriptomics)
124 200 - 186 400$
Match & Cover letter
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Job description
Text:
TL;DR
Immunology Senior Research Scientist (Spatial Transcriptomics): Leading the design and execution of spatial transcriptomics studies to drive mechanistic insights into disease biology and therapeutic response. Focus on integrating multi-modal datasets, optimizing tissue-based molecular profiling workflows, and collaborating across cross-functional teams to advance drug discovery and biomarker strategies.
Location: On-site in Seattle, WA (5 days per week)
Salary: $124,200 - $186,400
Company
is a global biotechnology company dedicated to creating transformative medicines for people with serious diseases.
What you will do
- Design and execute spatial transcriptomics studies to address key biological questions in disease-relevant tissues.
- Characterize tissue architecture, cellular microenvironments, and cell-cell interactions.
- Integrate spatial transcriptomics data with single-cell RNA-seq, proteomics, and imaging datasets.
- Develop and validate robust workflows for sample preparation, assay execution, and quality control.
- Partner with cross-functional teams in disease biology, pharmacology, and bioinformatics to inform program strategy.
- Mentor junior scientists and contribute to establishing best practices for spatial biology.
Requirements
- PhD in Immunology, Cell Biology, Molecular Biology, or related discipline with 2+ years of experience (or equivalent Master's/Bachelor's degree with relevant experience).
- Deep expertise in spatial transcriptomics and tissue-based molecular profiling.
- Proficiency in R and/or Python for spatial data analysis and visualization.
- Experience with fresh frozen and FFPE tissue processing and assay optimization.
- Strong understanding of transcriptomics, RNA biology, and cellular heterogeneity.
- Must be able to work on-site in Seattle, WA, five days per week.
Nice to have
- Hands-on experience with platforms like 10x Genomics Visium or Nanostring CosMx.
- Experience with histology, immunofluorescence, and multiplexed tissue profiling.
- Background in drug discovery, translational research, or clinical biomarker development.
- Knowledge of spatial proteomics or broader tissue-based profiling approaches.
Culture & Benefits
- Comprehensive medical, dental, and vision benefits.
- Generous paid time off, including company-wide summer and winter shutdowns.
- Educational assistance programs, including student loan repayment.
- 401(k) matching and charitable donation matching.
- Supportive environment focused on professional growth and scientific innovation.
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