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Immunology Senior Research Scientist (Spatial Transcriptomics)

124 200 - 186 400$
Формат работы
onsite
Тип работы
fulltime
Грейд
senior
Английский
b2
Страна
US
Вакансия из списка Hirify.GlobalВакансия из Hirify Global, списка международных tech-компаний
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Описание вакансии

Текст:
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TL;DR
Immunology Senior Research Scientist (Spatial Transcriptomics) (Spatial Transcriptomics/Immunology): Leading spatial transcriptomics studies to characterize disease-relevant tissues, cellular microenvironments, and therapeutic responses with an accent on tissue-based molecular profiling, assay optimization, and multimodal data integration. Focus on integrating spatial data with single-cell RNA-seq, proteomics, imaging, and histology, while developing reproducible workflows and translating findings into disease biology, biomarker, and drug-development strategies.

Location: Seattle, WA, United States; on-site five days per week

Base salary: $124,200–$186,400 per year, plus eligibility for an annual bonus and annual equity awards.

Company

Vertex is a global biotechnology company investing in scientific innovation to develop transformative medicines for serious diseases.

What you will do

  • Lead the design, execution, and optimization of spatial transcriptomics studies in disease-relevant tissues and model systems.
  • Characterize tissue architecture, cellular microenvironments, cell-cell interactions, and spatial organization.
  • Generate and interpret spatial data to support disease biology, target biology, mechanisms of action, and biomarker strategies.
  • Integrate spatial transcriptomics with single-cell RNA-seq, proteomics, imaging, histology, and other molecular profiling datasets.
  • Develop and validate workflows for sample preparation, assay execution, quality control, data review, and reproducible spatial biology standards.
  • Collaborate with disease biology, pharmacology, translational medicine, biomarker sciences, bioinformatics, and clinical development teams; mentor junior scientists and communicate technical findings.

Requirements

  • PhD in immunology, cell biology, molecular biology, biology, biomedical sciences, or a related discipline with 2+ years of relevant experience; or a master’s degree with 6+ years; or a bachelor’s degree with 8+ years.
  • Deep expertise in spatial transcriptomics and tissue-based molecular profiling, including transcriptomics, RNA biology, tissue architecture, and cellular heterogeneity.
  • Experience with fresh frozen and FFPE tissue processing, tissue quality assessment, assay optimization, and spatial biology platforms.
  • Experience integrating spatial data with single-cell, proteomic, imaging, and histologic datasets.
  • Working knowledge of spatial data analysis, visualization, and interpretation using R and/or Python.
  • Strong experimental rigor, problem-solving ability, communication skills, and effectiveness in a multidisciplinary matrixed environment.

Nice to have

  • Hands-on experience with platforms such as 10x Genomics Visium, NanoString CosMx, or similar technologies.
  • Experience with histology, immunofluorescence, image analysis, and multiplexed tissue profiling.
  • Experience in drug discovery, translational research, or clinical biomarker development, particularly in immunology or inflammation.
  • Familiarity with single-cell RNA-seq analysis, multi-omics integration, and spatial proteomics.

Culture & Benefits

  • Continuous learning and support for adopting advances in AI, technology, and automation.
  • Medical, dental, and vision benefits, generous paid time off, and week-long summer and winter company shutdowns.
  • Educational assistance programs, including student loan repayment, and a commuting subsidy.
  • Matching charitable donations, 401(k), annual bonus eligibility, and annual equity awards.
  • Equal employment opportunity, non-discrimination, and reasonable workplace accommodations.

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