2 дня назад
Scientist, Immunology
120 000 - 175 000$
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Scientist, Immunology (Cell Assays/Drug Discovery): Designing and optimizing cell-based assays to evaluate small-molecule mechanisms of action and support hit-to-lead and lead optimization with an accent on immune signaling, primary cell techniques, and cellular profiling. Focus on developing medium- to high-throughput assays, generating dose-response and IC50 data, troubleshooting complex experiments, and guiding multidisciplinary drug discovery decisions.
Location: Full-time onsite in Monrovia, California, United States
Salary: $120,000–$175,000 annually, depending on experience
Company
is a venture-backed biotechnology company combining nanotechnology, experimental science, machine learning, automation, and proprietary chemical data to discover and develop small-molecule therapeutics.
What you will do
- Design experiments to confirm the mechanisms of action of small-molecule hits from binding and virtual screens.
- Develop, optimize, and run cell-based assays to profile on-target and off-target activity.
- Adapt assays for medium- to high-throughput screening, dose-response analysis, and IC50 generation.
- Review literature and interpret experimental data to support internal immunology targets and therapeutic programs.
- Manage CROs for reagent development and in vitro testing when needed.
- Collaborate with chemists, computational scientists, and other multidisciplinary teams to guide project decisions.
Requirements
- PhD in immunology, molecular biology, cell biology, or a related field with 3+ years of small-molecule drug discovery experience, or an MSc with 10+ years of industry experience.
- Strong background in immunology and immune signaling pathways.
- Extensive hands-on experience with cell culture, cell-based assays, reporter assays, gene and protein expression, and intracellular techniques.
- Proficiency in primary cell isolation, differentiation, culture, and flow cytometry.
- Experience establishing robust small-molecule dose-response assays and generating IC50 data.
- Strong troubleshooting, organizational, interpersonal, communication, and collaborative research skills.
Culture & Benefits
- Hands-on, collaborative, and fast-paced research environment.
- Work alongside experts in artificial intelligence, chemistry, drug discovery, automation, and nanotechnology.
- Company stock option plan.
- 3% retirement safe harbor contribution.
- Fully paid health, dental, and vision insurance for employees and eligible family members, plus life and disability coverage.
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