Scientist I, Functional Bioassay & High-Throughput Screening (Biotech)

TL;DR

Scientist I, Functional Bioassay & High-Throughput Screening (Biotech): Developing and optimizing functional assays to generate high-quality data for AI/ML-enabled protein therapeutic design with an accent on biochemical and cell-based HTS platforms. Focus on executing high-throughput screening campaigns, optimizing assay workflows, and integrating automation to accelerate therapeutic discovery.

Location: Onsite in Somerville, MA

Salary: $102,000 – $143,000 USD

Company

A clinical-stage generative biology company pioneering the AI revolution in drug design and development by integrating machine learning with large-scale experimentation.

What you will do

• Design, optimize, and implement HTS-compatible biochemical and cell-based assays with automation integration.
• Execute plate-based HTS campaigns and interpret complex experimental datasets to support AI/ML design cycles.
• Troubleshoot assay performance, instrumentation, and reagent issues in partnership with automation colleagues.
• Contribute to multiple therapeutic programs, specifically focusing on ion channel, GPCR, and ADC-related assays.
• Maintain rigorous scientific records in electronic laboratory notebooks and prepare summaries for cross-functional meetings.

Requirements

• PhD in Cell Biology, Pharmacology, Biochemistry, Bioengineering, or related field; or MSc + 4 years experience; or BSc + 6 years experience.
• Hands-on experience with mammalian cell culture and plate-based assay workflows in a research setting.
• Proficiency with ELISA, HTRF, AlphaLISA, luminescence/fluorescence assays, or flow cytometry.
• Familiarity with high-throughput or medium-throughput screening (HTS) workflows and multiwell plate formats.
• Ability to analyze and present data using tools like GraphPad Prism, Spotfire, or similar platforms.
• Must be based in or able to work onsite in Somerville, MA.

Nice to have

• Experience with ion channel assays, GPCR assays, or ADC-related functional readouts.
• Experience with lab automation systems (e.g., HighRes, Beckman Biomek, Hamilton).
• Experience working with primary cells or stable cell line generation.
• Interest in applying functional biology to AI/ML-enabled therapeutic discovery.

Culture & Benefits

• Collaborative, fast-paced biotech environment at the intersection of ML and biology.
• Annual bonus and equity compensation.
• Competitive comprehensive benefits package.
• Focus on innovative, closed-loop experimental cycles to reduce drug discovery uncertainty.