Associate Scientist - Targeted Protein Degradation and Fetal Hemoglobin Induction

Location: Memphis, TN, United States of America; onsite research role

Salary: $65,520–$114,400 per year

Company

hirify.global conducts biomedical research and develops therapeutic strategies for serious diseases, including sickle cell disease.

What you will do

• Design, perform, optimize, troubleshoot, and analyze experiments evaluating targeted protein degradation strategies for fetal hemoglobin induction.
• Characterize the activity, selectivity, and mechanisms of action of PROTACs and molecular glue degraders targeting negative regulators of fetal hemoglobin expression.
• Evaluate compounds in immortalized erythroid cell lines, primary human erythroblast cultures, and biochemical and cellular assays.
• Contribute to preclinical evaluation in sickle cell disease mouse models and support translational drug discovery.
• Develop laboratory techniques and protocols, prepare scientific manuscripts, posters, presentations, SOPs, and reports, and communicate findings.
• Collaborate with multidisciplinary researchers, train less-experienced personnel, and support laboratory operations, equipment maintenance, inventory, and supplies.

Requirements

• Bachelor’s degree in a relevant scientific area.
• At least 7 years of research experience; at least 5 years with a Master’s degree or at least 2 years with a PhD.
• Strong experimental background in mammalian cell culture, molecular biology, biochemistry, or cellular assays.
• Experience with immunoblotting, flow cytometry, gene expression analysis, and protein characterization.
• Demonstrated ability to independently plan, execute, troubleshoot, and analyze experiments.
• Strong analytical, organizational, communication, and scientific problem-solving skills.
• Ability to work effectively in a collaborative, multidisciplinary research environment.
• Experience leading and supporting research experiments, with proven performance in an earlier or comparable role.

Nice to have

• PhD in Molecular Biology, Cell Biology, Biochemistry, Biomedical Sciences, Pharmacology, or a related field.
• Experience with high-throughput experimentation.
• Experience in erythroid biology, hemoglobin regulation, hematopoiesis, or sickle cell disease research.
• Familiarity with targeted protein degradation technologies, including PROTACs, molecular glues, E3 ubiquitin ligases, and the ubiquitin-proteasome system.
• Experience with primary human erythroid or hematopoietic cell cultures.
• Experience with preclinical mouse models or translational drug discovery research.
• Experience leading laboratory and scientific project coordination, maintenance, and research support activities.
• Experience guiding and training other laboratory personnel.
• Strong experimental skills, scientific curiosity, communication skills, team spirit, and willingness to learn new techniques.

Culture & Benefits

• Highly collaborative, multidisciplinary research environment with Senior Scientists, postdoctoral fellows, and cross-functional scientific collaborators.
• Opportunities to work across erythroid biology, chemical biology, protein degradation, mechanistic studies, compound optimization, and preclinical development.
• Opportunity to contribute to therapeutic discovery with potential clinical impact for patients with sickle cell disease.
• Benefits are available through hirify.global.

Hiring process

• Recruiting decisions involve human review and engagement; technology may support portions of the process.