Associate Principal Scientist, Immunology Discovery

Location: San Diego, California, United States; onsite, 10% travel; relocation support is available for domestic and international moves; visa sponsorship is available.

Salary: $142,400–$224,100 per year, plus potential annual bonus and long-term incentive.

Company

hirify.global is a pharmaceutical company developing medicines through discovery, translational research, and clinical development.

What you will do

• Lead translational discovery activities in immunology, inflammation, and autoimmunity.
• Design, execute, analyze, and interpret experiments to validate therapeutic targets and address key scientific questions.
• Develop in vitro, ex vivo, co-culture, tissue, and patient-derived models.
• Integrate mechanistic, pharmacology, transcriptomic, spatial, and biomarker data into decision-enabling translational packages.
• Represent the function on project teams and communicate plans, progress, risks, and recommendations to multidisciplinary audiences.
• Collaborate with discovery biology, translational medicine, biomarker sciences, data science, pharmacology, clinical development, academic, and CRO partners; mentor junior scientists.

Requirements

• Bachelor’s degree with 13+ years, Master’s degree with 9+ years, or Ph.D. with 5+ years in immunology, cell biology, molecular biology, translational science, biomedical sciences, or a related discipline, with relevant experience.
• Strong foundation in immunology, inflammation, autoimmunity, or related immune-mediated disease biology.
• Ability to independently design, troubleshoot, and interpret complex biological experiments.
• Hands-on experience with primary cell culture, immune-cell assays, co-culture systems, tissue models, or ex vivo human sample platforms.
• Ability to analyze biological, biochemical, immunological, and translational assay data and design follow-up studies.
• Clear communication of complex science to multidisciplinary audiences.
• Effective cross-functional collaboration and ability to contribute to multiple projects in a matrixed environment.

Nice to have

• Experience developing translational models of inflammatory or autoimmune disease, immune-cell activation, tissue inflammation, or immune-mediated pathology.
• Expertise with flow cytometry, cytokine profiling, imaging, multiplex tissue analysis, spatial biology, transcriptomics, or related platforms.
• Experience integrating human datasets with experimental models to define mechanism of action, pharmacodynamic biomarkers, responder hypotheses, or combination strategies.
• Experience supporting drug discovery from target validation through candidate nomination or early clinical translation.
• Familiarity with IBD, rheumatoid arthritis, hidradenitis suppurativa, psoriatic disease, lupus, asthma, or atopic dermatitis.
• Experience leading external collaborations or coordinating CRO work.

Culture & Benefits

• Regular employee status with medical, dental, vision, and other insurance benefits for employees and families.
• Retirement benefits including 401(k), paid holidays, vacation, compassionate leave, and sick days.
• Inclusive environment that values diverse perspectives, respectful challenge, collective problem-solving, scientific rigor, and high-quality documentation.
• Day shift; flexible work arrangements are not applicable.