Senior Scientist, Molecular Interactions (Biologics)

Location: South San Francisco, California, United States; onsite role with no travel required.

Salary: $131,400–$206,800 per year, plus potential annual bonus and long-term incentive.

Company

hirify.global develops and advances biologic therapeutics through multidisciplinary discovery programs.

What you will do

• Design, execute, troubleshoot, and interpret molecular interaction studies that guide program direction and molecule selection.
• Generate data from binding, affinity, kinetics, avidity, epitope binning, competition, receptor occupancy, internalization, signaling, and functional potency assays.
• Partner with antibody discovery, protein sciences, computational biology, developability, and therapeutic-area project teams to define assay strategies and communicate findings, risks, and recommendations.
• Apply surface plasmon resonance, Carterra, biolayer interferometry, and flow cytometry platforms to support biologics discovery.
• Develop and optimize assay formats, automation, data analysis, and visualization workflows to improve throughput, robustness, data quality, and turnaround time.
• Contribute to scientific presentations, publications, intellectual property, knowledge transfer, and development of junior scientists while following laboratory, documentation, data integrity, and safety requirements.

Requirements

• Bachelor's degree in a biological science field with 7+ years of relevant industry experience, or a Master's degree with 4+ years of relevant industry experience, or a Ph.D. in a biological science field with relevant experience.
• Ability to independently design, execute, and interpret complex experiments, including kinetic and affinity studies of protein interactions.
• Expertise in biomolecular interactions, protein characterization, and quantitative assay development, including hands-on experience designing, optimizing, and interpreting cell-based binding or functional assays.
• Hands-on experience with one or more interaction analysis platforms, such as surface plasmon resonance, Carterra, Biacore, biolayer interferometry, KinExA, or related technologies.
• Strong problem-solving, critical-thinking, troubleshooting, organizational, written communication, and verbal communication skills.
• Ability to deliver high-quality results within defined timelines and work effectively in a collaborative, team-oriented environment.

Nice to have

• Postdoctoral or industry experience supporting therapeutic antibody, multispecific, or other biologics discovery programs.
• Experience with epitope binning, competition assays, receptor pharmacology, developability assessment, and cell-based characterization of biologics, including flow cytometry, receptor binding or occupancy, internalization, signaling, reporter gene, proliferation, or other functional potency assays.
• Knowledge of antibody engineering, Fc biology, and relationships among protein structure, molecular interactions, and biological function.
• Familiarity with automation, high-throughput workflows, and modern data analysis and visualization tools.

Culture & Benefits

• Fast-paced, multidisciplinary research environment with collaboration across discovery and project teams.
• Medical, dental, vision, and other insurance benefits for employees and families.
• Retirement benefits including 401(k), paid holidays, vacation, compassionate leave, and sick days.
• Inclusive workplace that values diverse perspectives, respectful challenge, and collective problem-solving.