3 часа назад
Associate Scientist or Scientist (Genome Editing)
86 320 - 154 960$
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Associate Scientist or Scientist (Genome Editing) (Cellular Therapy/Genome Editing): Developing and characterizing genome-edited human hematopoietic stem cell products for sickle cell disease and other hematological diseases with an accent on lipid nanoparticle delivery, IND-enabling studies, and process development. Focus on flow cytometry, sequencing-based editing analysis, in vitro and xenotransplantation assays, and transferring reproducible processes to GMP manufacturing.
Location: Memphis, TN, United States; this is an onsite position and relocation assistance is available.
Salary: $86,320–$154,960 per year for the Associate Scientist or Scientist role. An Associate Scientist salary range of $65,520–$114,400 is also provided.
Company
conducts pediatric cancer and catastrophic disease research and develops therapies through bench-to-bedside programs and clinical collaborations.
What you will do
- Develop genome-editing strategies for human hematopoietic stem cells targeting sickle cell disease and other hematological diseases.
- Design and execute IND-enabling studies to characterize the pharmacology, efficacy, safety, and potency of genome-edited cellular products.
- Perform multicolor flow cytometry, FACS sorting, in vitro assays, and xenotransplantation studies.
- Develop RT-PCR, ddPCR, next-generation sequencing, single-cell sequencing, and editing-outcome analysis methods.
- Evaluate scale-up and closed-system processes, including process tracking, trending, and pilot-run reproducibility.
- Prepare protocols, batch records, and reports to standardize and transfer processes to a GMP facility while collaborating with multidisciplinary teams.
Requirements
- Bachelor’s degree in a relevant scientific field is required; a Master’s or PhD is highly preferred.
- Associate Scientist: 7+ years of research experience, or 5+ years with a Master’s degree, or 2+ years with a PhD.
- Scientist: 8 years of relevant post-degree experience with a Bachelor’s degree, 6 years with a Master’s degree, or 3 years with a PhD.
- Experience leading and supporting research experiments and coordinating laboratory or scientific projects.
- Experience guiding and training laboratory personnel, with proven performance in a comparable role.
- Regular and predictable onsite attendance in Memphis is required.
Nice to have
- Expertise in lipid nanoparticle-based delivery technologies.
- Experience with laboratory maintenance, research support activities, and process development.
Culture & Benefits
- Work with an interdisciplinary group of scientists and clinical researchers in the Therapeutic Genome Engineering group.
- Contribute to cellular therapy programs progressing toward Phase 1 clinical trials.
- Collaborate on internal discoveries, academic partnerships, and worldwide treatment initiatives.
- Relocation assistance is available for the Memphis-based position.
- Benefits are provided through St. Jude Children’s Research Hospital.
Hiring process
- Submit a cover letter with the application, addressed to Jonathan Yen, PhD.
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