19 часов назад
Associate Scientist/Scientist I, Translational Biology
88 000 - 144 000$
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Associate Scientist/Scientist I, Translational Biology (Flow Cytometry/LNP): Developing cross-species flow cytometry, tissue-processing, and immunoassay workflows to evaluate lipid nanoparticle delivery, immune activation, and therapeutic function with an accent on high-dimensional panels, viable cell isolation, and high-throughput screening. Focus on interpreting complex cytometry data, optimizing assays across preclinical species, and translating results into experimental strategy within AI-enabled scientific discovery workflows.
Location: Cambridge, MA, USA; office-based work is indicated for office-based employees.
Expected base salary: $88,000–$144,000 USD annually, with bonus potential and early-stage equity.
Company
builds AI-powered scientific systems and automated instruments for autonomous discovery across medicine, materials, and energy.
What you will do
- Serve as a flow cytometry subject-matter expert, designing and executing high-dimensional multi-parameter panels for LNP uptake, delivery, expression, immune activation, and phenotyping.
- Process liver, spleen, and whole-blood samples from mouse, rat, NHP, and human studies, generating viable single-cell suspensions for downstream analysis.
- Develop and run assays using flow cytometry, ELISA, multiplex immunoassays, qPCR, IncuCyte, and other cell biology readouts.
- Drive high-throughput and plate-based screening with liquid handling and automation teams.
- Analyze and present data, translate results into experimental strategy, and maintain high-integrity laboratory records.
- Mentor junior scientists and collaborate with biology, automation, and data teams.
Requirements
- BS with 5+ years or MS with 3+ years of hands-on laboratory experience in biology, biochemistry, immunology, biomedical engineering, or a related field.
- Advanced expertise in multi-parameter and spectral flow cytometry, including panel design, fluorophore selection, compensation/unmixing, instrument QC, acquisition, and interpretation.
- Hands-on FlowJo experience with gating strategy design and multi-parameter analysis.
- Expertise in ex vivo tissue processing and cell isolation, including perfusion, dissociation, density-gradient separation, and RBC lysis across multiple species.
- Experience with FACS, bead isolation, automated or plate-based flow acquisition, and electronic laboratory records.
- Ability to independently troubleshoot experiments, manage concurrent studies, and contribute to assay development.
Nice to have
- Experience with LNPs, nucleic acid therapeutics, tissue biodistribution, or tissue-resident immune cell analysis.
- Experience with qPCR, ddPCR, CRO coordination, assay SOPs, validation packages, ELISA development, automation, or liquid handlers.
- Experience with MSD, Luminex, or ELLA multiplex immunoassays.
Culture & Benefits
- Full-time U.S. employees receive medical, dental, and vision coverage.
- Benefits include employer-paid life and disability insurance, flexible time off, company holidays, and paid parental leave.
- Educational assistance, commuter benefits, bike-share memberships for office-based employees, and a subsidized lunch program are provided.
- Bonus potential and generous early-stage equity are available.
- International employees receive benefits tailored to their region.
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