2 дня назад
Scientist, Analytical Development (mRNA)
109 200 - 174 600$
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Scientist, Analytical Development (mRNA) (Cell Biology/Bioassay Development): Developing mechanism-driven cell-based bioassays for early-stage mRNA vaccines and therapeutics with an accent on assay robustness, biological relevance, and phase-appropriate analytical methods. Focus on designing experiments, translating exploratory Research assays into CMC-amenable methods, analyzing assay variability, and advancing methods toward qualification and QC transfer.
Location: 100% onsite in Norwood, Massachusetts, United States. Due to U.S. export control requirements, only U.S. persons are eligible.
Salary: $109,200–$174,600 per year, with potential bonus, incentive compensation, or equity eligibility.
Company
develops an mRNA technology platform and medicines, including vaccines and therapeutics.
What you will do
- Develop, optimize, and execute cell-based potency and biological activity assays for mRNA vaccines, therapeutics, and emerging modalities.
- Partner with Research to translate exploratory assays into robust, reproducible, CMC-amenable analytical methods.
- Generate proof-of-concept data and establish relationships between assay responses and mechanisms of action.
- Investigate assay performance, variability, failure modes, and technical issues through experimental design and data analysis.
- Develop and maintain cell systems and critical biological reagents, applying flow cytometry, ligand-binding, protein-expression, molecular biology, and other orthogonal methods.
- Advance assays from proof of concept through method development, pre-qualification, transfer, and lifecycle activities while communicating results and recommendations to cross-functional stakeholders.
Requirements
- U.S. person status is required because the position may involve access to export-controlled technology and data; non-U.S. persons cannot be sponsored for an export control license.
- 100% onsite presence in Norwood, Massachusetts is required.
- Ph.D. in Cell Biology, Molecular Biology, Immunology, Biochemistry, Bioengineering, Pharmaceutical Sciences, or a related field with 0–2 years of relevant experience; or M.S. with 8+ years; or B.S./B.A. with 10+ years of relevant industry experience.
- Hands-on mammalian cell culture experience and experience developing or optimizing cell-based assays.
- Experience with cell biology, bioassay development, assay performance evaluation, quantitative analysis, and technical troubleshooting.
- Strong scientific communication, organization, documentation, problem-solving, and cross-functional collaboration skills.
Nice to have
- Immunology or oncology research experience, including multiparameter flow cytometry and in vivo or ex vivo assays.
- Experience with reporter assays, flow cytometry, ELISA/MSD, ligand-binding assays, qPCR/ddPCR, imaging, or protein-expression assays.
- Experience with mammalian cell-line engineering, cell banking, and characterization of assay-critical cell systems.
- Experience with mRNA, nucleic-acid therapeutics, lipid nanoparticles, vaccines, oncology, immunology, or other advanced therapeutic modalities.
- Knowledge of critical quality attributes, analytical control strategies, and regulatory expectations for biological activity or potency assays.
Culture & Benefits
- In-person work model supporting hands-on collaboration, mentorship, and site-based operations.
- Competitive healthcare and voluntary benefit programs.
- Fitness, mindfulness, mental health, family planning, fertility, adoption, and surrogacy support.
- Paid vacation, volunteer days, sabbatical, global recharge days, and discretionary year-end shutdown.
- Savings and investment programs plus location-specific benefits.
- Smoke-free, alcohol-free, and drug-free work environment.
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