Sr. Manager, Pooled Screening Core - CAR Screening & Lead Selection, Cell & Genetic Medicines (Cell Therapy)

Location: Spring House, Pennsylvania, United States of America

Company

Johnson & Johnson MedTech develops healthcare solutions and medicines across Innovative Medicine and MedTech.

What you will do

• Establish and lead a centralized pooled screening core within Cell & Genetic Medicines.
• Develop scalable workflows covering library design, cloning, quality control, cell engineering, functional assays, sequencing readouts, and data interpretation.
• Translate project questions into rigorous study designs, controls, models, endpoints, and follow-up plans.
• Integrate pooled screening with arrayed screening, automation, CAR-T generation, vector, and assay development capabilities.
• Define the Core operating model, including intake, prioritization, resource planning, scheduling, execution, and data delivery.
• Lead and mentor scientists while monitoring quality, reproducibility, throughput, turnaround time, and portfolio impact.

Requirements

• Ph.D. in molecular biology, cell biology, immunology, bioengineering, biotechnology, or a related discipline, with substantial relevant industry experience; equivalent education and experience may be considered.
• Deep expertise in pooled screening technologies and experience designing, executing, troubleshooting, and interpreting complex screening studies.
• Experience leading scientific or multidisciplinary technical teams, mentoring talent, and fostering a collaborative, service-oriented culture.
• Ability to establish scalable workflows, manage concurrent priorities, and maintain high standards for quality, reproducibility, documentation, and delivery.
• Strong cross-functional leadership, relationship-building, written communication, and verbal communication skills.

Nice to have

• Experience applying pooled screening to CAR-T, T-cell engineering, cell therapy, or immuno-oncology discovery.
• Experience building or scaling a centralized technology platform, screening group, or service-oriented Core.
• Experience with automated or semi-automated high-throughput laboratory workflows and computational analysis of barcode-, sequencing-, or library-based screening data.
• Experience supporting projects from early discovery through candidate or lead selection and transferring emerging technologies across teams or sites.

Culture & Benefits

• Inclusive work environment that respects employee diversity, dignity, and individual contributions.
• Opportunity to build a scientific capability from the ground up within Cell & Genetic Medicines.
• Service-oriented, collaborative partnership with project and cross-functional teams.
• Equal opportunity employment and an inclusive interview process with accommodation support.