Principal Scientist (Inflammation)

Location: South San Francisco or Thousand Oaks, California, United States

Company

hirify.global is a biotechnology company developing medicines across oncology, inflammation, general medicine, and rare disease.

What you will do

• Lead discovery and translational biology for an immune-targeting therapeutic platform focused on autoimmune and inflammatory diseases.
• Design and execute in vitro, ex vivo, and in vivo studies evaluating immune-cell activity, target-cell depletion, immune pharmacology, and treatment durability.
• Develop immune-cell assays, co-culture systems, cytotoxicity assays, target-engagement readouts, and pharmacodynamic measurements.
• Build translational biology capabilities through immune-cell profiling, biodistribution studies, and biomarker development.
• Integrate experimental datasets to generate mechanistic insights and support candidate selection and advancement.
• Collaborate with discovery biology, protein engineering, delivery sciences, in vivo pharmacology, and translational safety teams.

Requirements

• PhD, PharmD, or MD with relevant experience; alternatively, a master’s degree with 5 years or a bachelor’s degree with 7 years of experience in drug discovery or academic settings.
• Deep expertise in lymphocyte biology, immune effector mechanisms, and immunology-related research.
• Strong experience with in vitro and ex vivo immunology, primary immune-cell assays, co-culture systems, cytotoxicity or target-cell depletion assays, and high-parameter flow cytometry.
• Experience with preclinical mouse models, immune-cell profiling, pharmacodynamic responses, and mechanism-of-action studies.
• Ability to communicate scientific proposals and results, document research, manage laboratory activities, and work effectively in multidisciplinary teams.

Nice to have

• Experience with ELISA, MSD, single-cell RNA sequencing, CRISPR/Cas9, omics data analysis, and small- or large-molecule drug discovery.
• Publications in high-impact journals and a record of independent scientific contributions.

Culture & Benefits

• Collaborative, innovative, and science-based working environment.
• Health, dental, vision, life, and disability insurance, plus flexible spending accounts.
• Retirement and savings plan with company contributions and stock-based long-term incentives.
• Annual bonus program, award-winning time-off plans, and career development opportunities.
• Flexible work models may apply where supported by the specific work location type.