Manager CMC Program Operations (AI)

Location: Cambridge, Massachusetts, United States

Base salary: $141,698–$173,186 per year, plus performance-based annual bonus and equity compensation.

Company

Develops curative genome-editing treatments for severe and life-threatening diseases.

What you will do

• Build and maintain integrated CMC project plans, including task interdependencies, critical paths, monitoring mechanisms, and schedule-risk tracking.
• Design and deploy AI-assisted and automated tools such as dashboards, natural-language status summaries, and predictive risk-flagging models.
• Publish recurring dashboards and executive-ready reports covering progress, critical-path changes, program health, and emerging risks.
• Manage CMC meetings, agendas, minutes, action items, risk registers, mitigation plans, and escalation processes.
• Coordinate Regulatory, Process Development, Manufacturing, Supply Chain, and Quality stakeholders to track RtQ and post-approval commitments.
• Modernize CMC workflows and scale successful digital tools, process improvements, and operational standards across the pipeline organization.

Requirements

• Strong project management fundamentals using MS Project, Smartsheet, or similar tools, with critical-path and risk-management experience.
• Experience using generative AI, automation, low-code/no-code platforms, scripting, Power BI, Tableau, or similar tools for operational reporting and risk analysis.
• Working knowledge of GMP, quality, supply chain, and regulatory requirements in biopharma or cell and gene therapy.
• At least 6 years of experience in biopharmaceutical or life sciences organizations, including CMC development, with at least 2 years in CMC or operations project management.
• Bachelor’s degree in a relevant field; PMP certification is preferred.
• Ability to influence without authority across matrixed teams, communicate effectively, manage stakeholders, and operate in an ambiguous environment.

Nice to have

• Cell and gene therapy experience.
• Hands-on experience building or deploying AI-enabled or automated operations-reporting tools.
• PMP certification.

Culture & Benefits

• Mission-driven work focused on curative genome-editing treatments.
• Values centered on collaboration, curiosity, innovation, execution, and high standards.
• Performance-based annual cash bonus.
• New-hire equity grant and eligibility for annual equity awards.
• Applications are accepted on a rolling basis until the position is filled.