Senior Engineer / Principal Engineer (Lentivirus Downstream Process Development)

Location: Somerset, New Jersey, United States; onsite. Applicants must be authorized to work in the United States and employment eligibility will be verified through E-Verify.

Base pay: $146,410–$192,164 USD per year, plus performance-based bonus and/or equity for eligible roles.

Company

hirify.global is a biotechnology company developing cell and gene therapy technologies, including CAR-T, TCR-T, NK cell-based therapies, and lentiviral vector platforms.

What you will do

• Design, optimize, and scale downstream purification processes for lentiviral vectors.
• Build mechanistic, hybrid, and in silico process models using engineering principles, machine learning, and process analytics.
• Develop clarification, chromatography, and tangential flow filtration workflows to improve vector recovery, purity, and potency.
• Translate bench-scale processes to GMP manufacturing, lead technology transfer, and provide troubleshooting support during clinical production.
• Design advanced process control strategies, including model predictive control and state estimators.
• Author and review development reports, SOPs, and CMC documentation while collaborating with upstream, analytical, manufacturing, and external CDMO teams.

Requirements

• PhD or MS in Chemical Engineering, Biomedical Engineering, Bioprocess Engineering, or a related field.
• At least 6 years of experience with a PhD or 8 years with an MS in biotech or pharmaceutical process development or manufacturing.
• Strong experience in downstream process development, purification, chromatography, and tangential flow filtration.
• Knowledge of bioprocess modeling and simulation; experience with Python and/or MATLAB.
• Understanding of GMP manufacturing and CMC strategies for clinical-stage products.
• English required; applicants must be authorized to work in the United States.

Nice to have

• Experience with lentiviral vectors, viral vectors, biologics, gene therapy, or advanced therapy process development.
• Experience developing vector processes for in vivo CAR-T generation and systemic delivery.
• Experience with purification processes at more than 50 L scale.
• Mandarin language skills.

Culture & Benefits

• Medical, dental, and vision insurance with a 401(k) plan and company match.
• Eight weeks of paid parental leave after three months of employment.
• Paid vacation, personal and sick time, floating holidays, and eleven company holidays.
• Additional flexible spending, health savings, disability, life insurance, commuter, family care, and well-being benefits.
• Benefits are available exclusively to permanent full-time employees; contractors are not eligible.