Scientist I, mRNA, Process Development (Biotech)

Location: Waltham, Massachusetts, United States

Salary: $105,000–$145,000 per year

Company

hirify.global is a technology-driven biotechnology company providing integrated technologies, services, and manufacturing expertise for advanced therapies from design through commercialization.

What you will do

• Lead development, optimization, and scale-up experiments for mRNA production and purification.
• Characterize mRNA samples using electrophoresis, spectrophotometry, HPLC, and UPLC.
• Support tech transfer of mRNA-based therapeutics from process development into manufacturing.
• Collaborate with MSAT, analytical development, external clients, and business development teams.
• Prepare statements of work and proposals, communicate experimental results, and develop SOPs and technical documents.

Requirements

• BS or MS in Microbiology, Bioengineering, Biochemistry, or a related discipline, plus 8+ years of relevant experience.
• At least 4 years of experience working with mRNA-based therapeutics.
• Hands-on experience with in-vitro transcription, plasmid DNA linearization, mRNA downstream processing, TFF, and chromatography.
• Experience operating ÄKTA Avant/Pure systems and Repligen KrosFlow Kr2i filtration skids.
• Experience with mRNA process technology transfer and scaling from bench scale to GMP manufacturing.

Nice to have

• Experience with mRNA-LNP formulation and mixing technologies.
• Experience using JMP for Design of Experiments and data analysis.
• Familiarity with GMP regulations, Quality by Design principles, and regulatory filing documentation.

Culture & Benefits

• Regular employment within the Process Development department.
• Work with cross-functional teams and external clients on advanced mRNA therapeutics.
• Equal employment opportunity and reasonable accommodations for qualified applicants with disabilities.