12 дней назад
Scientist Erythroid Biology
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Scientist Erythroid Biology (siRNA/RNA therapeutics): Designing and conducting in vitro and ex vivo assays, developing human primary cell-based systems, and supporting target validation and mechanism-of-action studies with an accent on erythroid biology, hematopoiesis, and multi-color flow cytometry. Focus on optimizing qPCR and RNA-based readouts, collaborating across drug discovery teams, and contributing to IND-enabling studies and data packages.
Location: Thousand Oaks, California, United States
Company
is a biotechnology company developing medicines across oncology, inflammation, general medicine, and rare disease.
What you will do
- Design and execute in vitro and ex vivo assays evaluating siRNA delivery and function.
- Develop human primary cell-based systems for erythroid biology research.
- Support target validation and mechanism-of-action studies for siRNA therapeutics.
- Establish and optimize multi-color flow cytometry panels, qPCR, and RNA-based readouts.
- Collaborate with Delivery/Chemistry, Translational, and Biomarker teams.
- Contribute to IND-enabling studies and data packages.
Requirements
- Doctorate degree; alternatively, a master's degree plus 2 years of scientific experience or a bachelor's degree plus 4 years of scientific experience.
- Experience with siRNA or RNA therapeutics, including delivery or functional assays.
- Background in erythroid biology, hematopoiesis, and cell-based functional assays.
- Strong experience with multi-color flow cytometry and familiarity with gene expression, qPCR, RNA assays, and target engagement assays.
- Experience working in cross-functional drug discovery teams.
Nice to have
- Knowledge of hemoglobinopathies, conjugated delivery systems, CRISPR, or gene editing.
Culture & Benefits
- Employee benefits include medical, dental, vision, life, and disability insurance.
- Retirement and savings plan with company contributions and flexible spending accounts.
- Discretionary annual bonus program and stock-based long-term incentives.
- Paid time-off plans and flexible work models where applicable.
- Career development opportunities within a collaborative, science-based environment.
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