Scientist (Mass Spectrometry)

Location: Cambridge, MA; onsite

Base salary: $123,300–$150,700 per year, plus performance-based annual bonus and equity compensation.

Company

hirify.global develops genome editing treatments intended to address severe and life-threatening diseases.

What you will do

• Design and execute discovery proteomics workflows, including sample preparation, LC-MS/MS acquisition, and downstream bioinformatic analysis.
• Develop immunopeptidomics workflows using MHC class I/II immunoaffinity purification, peptide processing, and nanoflow LC-MS/MS.
• Analyze complex proteomics datasets and translate findings into actionable insights about biomarkers and immune recognition.
• Apply top-down or native mass spectrometry to characterize protein structure, complex integrity, and post-translational modifications.
• Select and optimize separation chemistry and mass spectrometry platforms for specific analytes and biological questions.
• Lead assay development and discovery projects, author methods and SOPs, and collaborate with immunology and process development teams.

Requirements

• Hands-on experience with immunopeptidomics, including MHC/HLA immunoprecipitation and low-abundance peptide LC-MS/MS.
• Experience with native and/or intact protein mass spectrometry and a strong bioanalytical or structural mass spectrometry background.
• Familiarity with HLA-binding prediction tools and immunopeptidomics-specific proteomics search software.
• PhD in a biological or relevant technical/engineering field, or equivalent education and experience.
• 0–3+ years of relevant experience post-PhD, or 6–9+ years with an MS or 8–11+ years with a BS.
• Strong problem-solving, communication, organizational, prioritization, and data-quality skills; ability to lift up to 15 pounds occasionally.

Nice to have

• Top-down or native protein mass spectrometry experience.

Culture & Benefits

• Mission-driven environment focused on curative genome editing treatments.
• Performance-based annual cash bonus.
• New-hire equity grant and eligibility for annual equity awards.
• Applications are accepted on a rolling basis until the position is filled.