6 дней назад
Scientist, Discovery Pharmacology
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Scientist, Discovery Pharmacology (Immunology/Cell Biology): Advancing drug discovery programs from target validation through candidate selection with an accent on neutrophil biology, primary-cell assays, imaging, and mechanism-of-action studies. Focus on optimizing in vitro and ex vivo assay cascades, performing flow cytometry and high-content imaging, and using quantitative data to guide therapeutic candidate progression.
Location: Bridgewater, New Jersey, United States; full-time, in-person presence required.
Company
is a global biopharmaceutical company developing treatments for patients with serious and rare diseases.
What you will do
- Advance drug discovery programs from target validation through candidate selection.
- Culture, maintain, and characterize primary cells and mammalian cell lines for in vitro and ex vivo assays.
- Develop, optimize, validate, and execute cell-based and functional assay cascades to assess compound activity, efficacy, selectivity, and off-target potential.
- Perform neutrophil functional assays, including NET formation and flow cytometry-based assays, as well as fluorescence microscopy and quantitative image analysis.
- Design mechanism-of-action studies using gene expression profiling and protein-based analytical platforms.
- Analyze in vivo study samples using flow cytometry, ELISA, Western blotting, imaging assays, statistics, and data visualization.
Requirements
- PhD with at least 2 years of experience, or MS with at least 7 years of experience, in immunology, molecular and cellular biology, or a related field.
- Strong expertise in innate immunity, particularly neutrophil biology.
- Hands-on experience with primary and mammalian cell culture and development and execution of in vitro assays.
- Hands-on expertise in fluorescence microscopy, confocal microscopy, and high-content imaging systems.
- Strong communication, problem-solving, organization, time-management, and data-quality skills.
- Ability to work full-time in person at the Bridgewater, NJ office.
Nice to have
- Experience conducting NET formation assays in primary cells.
- Familiarity with respiratory, immune-mediated, or autoimmune diseases.
- Recognized writing or presentation skills.
Culture & Benefits
- Medical, dental, vision, mental health, and employee assistance program support.
- Paid time off, fertility and family-forming benefits, caregiver support, and flexible schedules with purposeful in-person collaboration.
- 401(k) matching, annual equity awards, employee stock purchase plan, and company-paid life and disability insurance.
- Learning resources, skill-building workshops, leadership programs, mentorship, and networking opportunities.
- Employee resource groups, service programs, and opportunities to volunteer and contribute to the community.
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