7 дней назад
Associate Scientist, Potency Assay Development (Gene Therapy)
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Associate Scientist, Potency Assay Development (Gene Therapy): Developing, optimizing, and qualifying cell-based and molecular potency assays for AAV, siRNA, and antibody-oligonucleotide conjugate programs with an accent on qPCR, ELISA, Western blotting, mammalian cell culture, and assay reproducibility. Focus on supporting preclinical manufacturing and product characterization, analyzing assay data, troubleshooting workflows, and transferring qualified methods to GMP laboratories.
Location: Onsite in Tarrytown, New York, United States
Company
is a biotechnology company developing and commercializing medicines for serious diseases, including gene therapy programs.
What you will do
- Develop, optimize, and qualify cell-based potency assays for AAV, siRNA, and antibody-oligonucleotide conjugate programs.
- Execute qPCR, ELISA, Western blot, cell-based, and molecular assays with strong attention to reproducibility.
- Maintain adherent and non-adherent mammalian cell cultures, including engineered and stable cell lines.
- Operate flow cytometers, plate readers, and automated laboratory systems to generate assay data.
- Analyze results using statistical methods and document experiments, conclusions, and decisions in the electronic lab notebook.
- Support preclinical sample testing, assay troubleshooting, cross-functional presentations, and transfer of qualified assays to GMP laboratories.
Requirements
- Bachelor's degree with at least 3 years of relevant laboratory experience, or a Master's degree with 0–2 years of experience.
- Hands-on experience with cell-based assays, preferably potency assays.
- Experience with qPCR, ELISA, and CE-Western blotting.
- Strong mammalian cell culture skills and the ability to execute experiments independently.
- Strong organizational skills and the ability to manage multiple workflows in a fast-paced environment.
- Ability to work onsite in Tarrytown, New York.
Nice to have
- Experience measuring mRNA expression with qPCR and developing luciferase reporter-based assays.
- Experience with immunofluorescence staining, imaging-based assay readouts, automated imaging, or plate-based analytical platforms.
- Experience using GraphPad Prism for data analysis.
Culture & Benefits
- Inclusive workplace and equal opportunity employment environment.
- Competitive total rewards package that may include bonuses, equity awards, retirement benefits, health insurance, paid time off, and family support benefits.
- Onsite collaboration is expected for this role.
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