5 дней назад
R&D - Intrepide-Principal Scientist I, Biologics Discovery & Innovation - SZ (Biologics Discovery)
Мэтч & Сопровод
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Описание вакансии
Текст:
TL;DR
R&D - Intrepide-Principal Scientist I, Biologics Discovery & Innovation - SZ (Biologics Discovery): Leading antibody and biologics discovery programs from antigen design and immunization through hit identification, lead selection, and key development milestones with an accent on display technologies, single B cell cloning, and advanced antibody modalities. Focus on coordinating multidisciplinary teams and CRO partners, evaluating emerging platforms, and applying antibody engineering, AI-driven screening, and laboratory automation to accelerate candidate progression.
Location: Suzhou, China
Company
develops medicines and advances scientific research across global therapeutic areas.
What you will do
- Lead or co-lead antibody discovery programs from antigen design and immunization through hit identification, screening, and lead selection.
- Design antigen engineering strategies, including recombinant proteins, hapten conjugation, and cell-based immunization.
- Provide technical leadership across display screening, single B cell cloning, hybridoma, and other antibody discovery platforms.
- Lead discovery campaigns for bispecific and multispecific antibodies and evaluate emerging modality-specific approaches.
- Coordinate internal teams and CRO partners, defining scopes, deliverables, quality standards, milestones, and timelines.
- Support lead optimization through affinity maturation, humanization, liability assessment, AI-driven screening, machine learning-assisted design, and automated workflows.
Requirements
- Ph.D. in Immunology, Biochemistry, Bioengineering, or a closely related discipline.
- At least 5 years of experience in antibody discovery, including display technologies, B cell-based discovery, hit identification, and lead selection.
- Hands-on expertise in at least two discovery platforms, such as phage display, yeast display, ribosome display, single B cell cloning, or hybridoma technology.
- Experience with antigen design, immunization strategy, functional screening, triage, and lead nomination.
- Experience leading cross-functional discovery programs and managing CRO partnerships in global, cross-cultural settings.
- Strong scientific communication, project management, mentoring, and technology evaluation skills.
Nice to have
- Experience with bispecific or multispecific antibodies and nanobody/VHH discovery workflows.
- Peer-reviewed publications, patents, or significant internal program milestones in antibody discovery.
- Experience with AI-based antigen design, computational screening, or laboratory automation.
Culture & Benefits
- Work in a global R&D environment focused on scientific progress and improved patient outcomes.
- Collaborate with multidisciplinary internal teams and external research partners.
- Support scientific talent development, continuous innovation, intellectual openness, and collaborative excellence.
- Equal employment opportunities are provided regardless of protected personal characteristics.
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