Principal Scientist PBPK and Mechanistic Modeling (Pharmacokinetics)

Location: Beerse, Antwerp, Belgium; full-time on-site work with 3 working days on site required

Base pay: €79,800–€137,770 annually, plus an annual bonus or sales commissions depending on the role and location.

Company

Johnson & Johnson MedTech develops healthcare solutions and medicines through science-based innovation across Innovative Medicine and MedTech.

What you will do

• Develop and apply translational PBPK and mechanistic PK/PD modeling strategies for candidate drugs and dosing regimens.
• Integrate in vitro, in vivo, pharmacokinetic, pharmacodynamic, efficacy, and safety data across emerging therapeutic modalities.
• Verify model predictions using clinical PK, PD, efficacy, and safety datasets.
• Collaborate with clinical pharmacology, pharmacometrics, in vitro, and in vivo experts.
• Author scientific reports, internal and external presentations, and peer-reviewed publications.

Requirements

• PhD in pharmacokinetics, pharmacometrics, biomedical engineering, systems pharmacology, or a related life science field; alternatively, a related background with 3+ years of relevant industry experience.
• Strong expertise in PBPK or mechanistic PK/PD modeling and hands-on translational modeling experience.
• Experience with Simcyp, SimCYP Designer, or related tools, including Monolix, NONMEM, SimBiology, MATLAB, or R.
• Understanding of experimental systems and in vivo pharmacokinetic studies relevant to model-informed data generation.
• Strong scientific, written, and oral communication skills in English, independence, organization, and multidisciplinary collaboration.
• Ability to work full-time on site, including 3 working days on site.

Nice to have

• Experience guiding experimental design for fit-for-purpose mechanistic model development.
• Strong mathematical problem-solving, critical data analysis, and large-dataset and literature interpretation skills.

Culture & Benefits

• Inclusive work environment focused on diversity, dignity, and individual merit.
• Annual bonus with a target based on pay grade and location, or sales commissions where applicable.
• Vacation, parental leave of at least 12 weeks, bereavement leave, caregiver leave, and volunteer leave.
• Well-being reimbursement and financial, physical, and mental health programs.
• Insurance plans and service anniversary and recognition awards, subject to plan and location terms.