Senior/Executive Medical Director, Clinical Development (New Indications) (Neurology)

Location: South San Francisco, California, United States; onsite Tuesday-Thursday. Remote candidates may be considered case by case. Travel of approximately 20-30% is required.

Salary: $300,000-$400,000 USD annually, plus annual bonus and equity participation.

Company

hirify.global is a precision medicines biotechnology company developing treatments for autoimmune and neurological diseases.

What you will do

• Lead the design, planning, and execution of Phase 1 and Phase 2 studies for A-005, a CNS-penetrant TYK2 inhibitor, and other pipeline molecules.
• Develop clinical development plans, study synopses, protocols, and integrated strategies for new indications.
• Serve as Medical Monitor, overseeing patient safety, protocol amendments, data review, and scientific integrity.
• Partner with Clinical Operations, Biostatistics, Regulatory Affairs, Translational Sciences, Biomarkers, Pharmacology, Commercial, and Medical Affairs.
• Lead interactions with DSMBs, FDA, EMA, PMDA, investigators, KOLs, academic collaborators, and scientific conferences.
• Mentor junior medical staff and help build clinical development capabilities.

Requirements

• MD required; neurology experience required. Neurology board certification or fellowship training is highly desired.
• 10+ years of pharmaceutical or biotechnology industry experience in clinical development, with significant neurology experience.
• Experience leading Phase 1 and Phase 2 studies from design through data readout.
• Successful FDA and EMA regulatory interactions and experience preparing IND or CTA submissions.
• Strong knowledge of early clinical development, dose-finding, biomarker integration, adaptive trial designs, and evaluation of preclinical and clinical data.
• Leadership, communication, strategic thinking, and cross-functional influence in a matrixed environment.

Nice to have

• Experience with JAK/TYK2 inhibitors or related immunomodulatory mechanisms.
• Experience in immunology, autoimmune diseases, rheumatology, dermatology, indication expansion, or lifecycle management.
• Established neurology KOL relationships and familiarity with expedited regulatory pathways such as Breakthrough Therapy and Fast Track.
• Experience at a small or mid-sized biotechnology company.

Culture & Benefits

• Collaborative, science-driven environment focused on improving patient outcomes.
• Health, dental, and vision insurance, with premiums paid at 90% for employees and 80% for dependents.
• 401(k), generous or unlimited PTO for exempt employees, annual bonus, and stock options.
• Free Genentech Bus & Ferry Share access, onsite gym, stocked kitchen, and $100 monthly cell phone stipend.