Research Scientist, Bioanalytical Sciences & Assay Development (AI-Driven Drug Discovery)

Location: Onsite at the San Diego Headquarters, United States

Salary: Research Scientist I $113.6K–$142K annually; Research Scientist II $124.8K–$156K annually

Company

hirify.global is a clinical-stage life-science and technology company developing medicines through an AI-driven drug discovery and development platform.

What you will do

• Develop MS-based assays and screening workflows for Hit Identification, including Affinity Selection Mass Spectrometry and related approaches.
• Design and execute bioanalytical, biochemical, in vitro ADME/DMPK, and physicochemical property assays.
• Develop and optimize LC-MS/MS methods, troubleshooting sensitivity, selectivity, matrix effects, reproducibility, and assay performance.
• Build automated and high-throughput workflows and support MS, LC-MS, and laboratory automation instrumentation.
• Generate high-quality datasets for AI/ML-driven compound design and optimization.
• Collaborate with biology, screening, medicinal chemistry, DMPK, computational, and AI teams to translate experimental results into actionable insights.

Requirements

• Ph.D. in bioanalytical chemistry, mass spectrometry, chemical biology, drug metabolism/pharmacokinetics, pharmaceutical sciences, biochemistry, or a related field, with approximately 0–5 years of relevant experience; or an M.S. with significant relevant industry experience.
• Strong foundation in mass spectrometry, bioanalytical science, and assay development, preferably including hands-on LC-MS/MS experience.
• Experience developing, optimizing, and troubleshooting bioanalytical, biochemical, or screening assays.
• Understanding of quantitative assay design, experimental controls, data quality, and troubleshooting.
• Strong scientific problem-solving and collaboration skills, with interest in AI/ML-enabled drug discovery and molecular design.

Nice to have

• Experience with MS-based screening or HitID approaches, including ASMS.
• Experience with in vitro ADME/DMPK or physicochemical property assays such as solubility, logD, and ePSA.
• Experience with SCIEX, Agilent, Thermo, or comparable MS/LC-MS platforms.
• Experience with laboratory automation, high-throughput screening or experimentation, and automated data processing.

Culture & Benefits

• Company-paid healthcare, flexible spending accounts, voluntary life insurance, and 401(k) matching.
• Uncapped vacation.
• Work in a new state-of-the-art facility with an onsite gym and dining.
• Inclusive environment focused on collaboration across diverse backgrounds and disciplines.