Senior Scientist, siRNA Analytical Development (siRNA)

Location: North Chicago, Illinois, United States; Worcester, Massachusetts, United States

Salary: $109,500–$208,500 per year

Company

hirify.global develops medicines and solutions across immunology, oncology, neuroscience, and aesthetic medicine.

What you will do

• Develop, optimize, and execute analytical methods for siRNA and oligonucleotide characterization.
• Perform purity assessment, identity confirmation, quantification, and impurity profiling using HPLC, LC-MS, and spectroscopy.
• Develop analytical strategies for modified siRNAs, antibody-siRNA conjugates, and novel delivery formats.
• Generate, review, and interpret analytical data while maintaining data integrity and quality standards.
• Maintain experimental records, SOPs, and analytical reports.
• Partner with synthesis, antibody conjugation, screening, and CMC teams and present scientific findings.

Requirements

• BS, MS, or PhD in Chemistry, Chemical Biology, Biochemistry, or a related field.
• Typically 0–4+ years of relevant experience with a PhD, 8–10+ years with an MS, or 10–12+ years with a BS.
• Hands-on experience characterizing siRNA, ASO, or related modalities.
• Strong proficiency in RP-HPLC, IEX-HPLC, IP-RP-HPLC, LC-MS, and UV spectroscopy.
• Knowledge of RNA chemistry, oligonucleotide modifications, conjugation chemistry, and chromatographic and mass spectrometric data analysis.
• Ability to troubleshoot complex analytical problems, improve methods independently, and communicate scientific findings clearly.

Culture & Benefits

• Collaborative and innovative scientific environment.
• Paid vacation, holidays, and sick leave.
• Medical, dental, and vision insurance for eligible employees.
• 401(k) benefits for eligible employees.
• Eligibility for short-term and potentially long-term incentive programs.